Caracterización funcional de la interacción de la proteïna

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Caracterización funcional de la interacción de la
proteïna p53 con la ubiquitina ligasa HERC2
Mónica Cubillos Rojas
ADVERTIMENT. La consulta d’aquesta tesi queda condicionada a l’acceptació de les següents condicions d'ús: La difusió
d’aquesta tesi per mitjà del servei TDX (www.tdx.cat) i a través del Dipòsit Digital de la UB (diposit.ub.edu) ha estat
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o marc aliè a TDX o al Dipòsit Digital de la UB (framing). Aquesta reserva de drets afecta tant al resum de presentació de
la tesi com als seus continguts. En la utilització o cita de parts de
la tesi és obligat indicar el nom de la persona autora.
ADVERTENCIA. La consulta de esta tesis queda condicionada a la aceptación de las siguientes condiciones de uso: La
difusión de esta tesis por medio del servicio TDR (www.tdx.cat) y a través del Repositorio Digital de la UB
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partes de la tesis es obligado indicar el nombre de la persona autora.
WARNING. On having consulted this thesis you’re accepting the following use conditions: Spreading this thesis by the
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Caracterización funcional
de la interacción de la proteína p53
con la ubiquitina ligasa HERC2
Mónica Cubillos Rojas
Tesis Doctoral
2014
Listado de abreviaturas
Listado de abreviaturas
53BP1: p53 binding protein 1
AMPK: AMP activated protein kinase
Apaf1: Apoptosis protease activating factor 1
APC: Adenomatous polyposis coli
ARC: Apoptosis repressor with caspase recruitment domain
AS: Angelman syndrome
Atg8: Autophagy-related protein 8
ATM: Ataxia telangiectasia mutated
ATP: Adenosine TriPhosphate
ATR: Ataxia telangiectasia and Rad3 related
Bak: Bcl2 antagonist/killer 1
Bax: Bcl2-associated X protein
BCA: Bicinchoninic acid assay
Bcl-2: B-cell CLL/lymphoma 2
Bid: BH3 interacting domain death agonist
BRCA1: Breast cancer 1
BSA: Bovine serum albumin
CDC25A: Cell division cycle 25A
CDK: Ciclin dependent kinase
cDNA: Complementary DNA
Ceb1: Cyclin E-binding protein-1
CHC: Clathrin heavy chain
Chk1: Checkpoint Kinase 1
Chk2: Checkpoint Kinase 2
CHX: Cicloheximida
CK1 α: Casein kinase 1α
COP1: Constitutive photomorphogenic protein
CP110: Centriolar coiled coil protein
CPH: CUL7, PARC, HERC2
DBD: DNA binding domain
DMEM: Dulbecco's Modified Eagle's medium
183
Listado de abreviaturas
DNA: Deoxyribonucleic acid
DNA-PK: DNA-dependent protein kinase
DTT: Dithiothreitol
DYRK2: Tyrosine-phosphorylation-regulated kinase 2
E6AP: E6 associated protein
EDTA: Ethylenediaminetetraacetic acid
EMT: Epithelial mesenchymal transition
FAT10: HLA-F-adjacent transcript 10
FGF: Fibroblast growth factor
FHA: Forkhead associated domain
Gadd45A: Growth arrest and DNA damage inducible alpha
GAP: GTPase activator protein
GAPDH: Glyceraldehyde 3-phosphate dehydrogenase
GDP: Guanosine DiPhosphate
GEF: Guanine nucleotide exchange factor
GLUT1: Glucose transporter 1
GST-α1: Glutathione-S-transferase α1
GTP: Guanosine TriPhosphate
HAT: Histone acetyltransferases
HAUSP: Herpesvirus associated ubiquitin specific protease
HECT: Homologous to E6AP C-terminus
HIPK2: Homeodomain interacting protein kinase 2
HLTF: Helicase-like transcription factor
hPLIC: Human proteins linking integrin-associated proteins and cytoskeleton
HPV: Human papilloma virus
IFN-α/β: Inteferon α/β
IP: Inmunoprecipitación
IRF3: Interferon Regulatory Factor 3
IRF4: Interferon regulatory 4
ISG15: Interferon induced gene
jdf2: juvenile development and fertility 2
184
Listado de abreviaturas
kDa: Kilodalton
Killer/DR5: Death domain containing receptor
LDS: Lithium dodecyl sulfate
LPS: Lipopolisacárido
MC1R: Melanocortin 1 receptor
MDC1: Mediator of DNA damage checkpoint 1
MDM2: Mouse double minute 2
MET: Mesenchymal mesénquima-epitelio transition MET
M-H: Mib-HERC2
miRNAs : microRNAs
MITF: Microphthalmia associated transcription factor
MLH1: MutL homolog 1
MRN: Mre11-Rad50-Nbs1
mRNA: Messenger RNA
MSH2: MutS homolog 2
mTOR: Mammalian target of rapamycin
MYBBP1A: Myb- binding protein 1A
NES: Nuclear exportation signal/ sequence
NEURL4: Neuralized homolog 4
NF2: Neurofibromin 2
NHEJ: Non homologous end joining
NLS: Nuclear localization signal/sequence
NQO1: NADPH quinone oxidoreductase
NTF2: Nuclear transport factor 2
p53AIP1: p53-regulated apoptosis inducing protein 1
p53R2: Ribonucleotide reductase M2 B
PAGE: Polyacrylamide gel electrophoresis
PBS: Phosphate buffered saline
PCAF: p300 and CBP associated factor
PCNA: Proliferating celular antigen
PCR: Polymerase chain reaction
185
Listado de abreviaturas
PERP: TP53 apoptosis effector
PI: Suero preinmune
PIG3: p53 inducible gene 3
PIG6: p53 inducible 6
Pirh2: p53 induced protein with a RING-H2 domain
PKC: Protein kinase C
PMS2: Postmeiotic segregation increased 2
PMSF: Phenylmethylsulfonyl fluoride
PTEN: Phosphatase and tensin homolog
PUMA: p53 upregulated modulator of apoptosis
PWS: Prader-Willi syndrome
Ran: Ras related nuclear protein
RAP80: Receptor associated protein 80
Rb: Retinoblastoma
Rheb: Ras homolog enriched in brain
RING: Really interesting new gene
rjs: runty, jerky, sterile
RLD: RCC1-like domain
RNF168: Ring finger protein 168
RNF8: Ring finger protein 8
ROS: Reactive oxygen species
RP: Ribosomal protein
RPA: Replication protein A1
rRNA: Ribosomal RNA
SDS: Sodium dodecyl sulfate
SH3: Src homology 3
siRNA: Small interference RNA
SLC24A4: Solute carrier family 24, member 4
SMC1: Structural maintenance of chromosomes 1A
Smyd2: SET and MYND domain containing 2
SNP: single nucleotide polymorphism
186
Listado de abreviaturas
SUMO: Small ubiquitin-like modifier
TA : Transactivación
TBST: Tris-Buffered Saline and Tween 20
TFIIH: Transcription factor IIH
TGFβ: Tumor growth factor β.
TNFα : Tumor necrosis factor α
TRAIL: TNF related apoptosis inducing ligand
TSC1: Tuberous sclerosis 1
TSC2: Tuberin
TSP-1: Trombospondina
TYRP1: Tyrosinase-related protein 1
UV: Ultravioleta
VEGF: Vascular endothelial growth factor
x-CT: Subunit of the cystine/glutamate transporter),
XPA: Xeroderma pigmentosum, complementation group A
XPC: Xeroderma pigmentosum, complementation group C
XPG: Xeroderma pigmentosum, complementation group G
XPG-ERCC1: Excision repair cross-complementing rodent repair deficiency
187

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