Our Subcutaneous Immunoglobulin Replacement
Therapy Experience with Intravenous Preparation
Intravenous immunoglobulin (IVIG) has
been used for primary immune deficiency (PID) treatment
for many years. Recently, immunoglobulin (Ig) administration
via subcutaneous route has become popular. Subcutaneously
administered immunoglobulin (SCIG) provides more stable
serum Ig levels and has lower incidence of systemic adverse
effects than intravenous route. This method increases quality
of life by self administration or parent-administration at home.
Immunoglobulin preparations designed for subcutaneous
administration became available in Europe and USA by 2006.
However, now there has not been subcutaneous preparation
available in Turkey. In that case, some of IVIG preparations could
be given subcutaneously. Here, our aim is to reveal our clinical
experience with 3 PID patients in whom we used IVIG preparation
(Kiovig®) for subcutaneous route.
The patient and methods: Three patients with PID were
selected for SCIG. The patient have been treated with IVIG (0.40.6gr/kg/dose) every 3-4 weeks. 3-4 week dosage calculated,
then divided into 3-4 doses and given. They have been followed
up for the last 4-5 months since then.
Case1: 19-year-old male was diagnosed with CVID with
complaints of recurrent lower respiratory tract infections 4 years
ago. He was treated with IVIG every 3-4 weeks according to his
Ig levels and clinical evaluations. He weighs at 78 kilograms and
was taking 35g IVIG every 3-4 weeks. For the last 5 months, he
has been treated with 10g IVIG per week subcutaneously. First 6
doses were given in hospital under medical supervision, but now
he is taking SCIG at home. Both he and his parents are capable
of performing the procedure. His symptoms due to lung problem
(bronchiectasis) and spirometry evaluation as well as serum Ig
levels got better.
Case2: 10-year-old female was diagnosed with CVID and was
treated with IVIG every 3-4 weeks according to her Ig levels
and clinical evaluations. She weighs at 20 kilograms and was
taking 10g IVIG every 2-3 weeks. For the last 4 months she has
been treated with 5g SCIG per week. First 8 doses were given
in hospital under medical supervision until her mother learned
the procedure. But now she is taking her SCIG at home. At the
beginning, she experienced urticarial rash a couple of time over
the skin SCIG given.
Submit Manuscript | http://medcraveonline.com
Volume 3 Issue 2 - 2016
Öner Özdemir* and Dilek Bingöl-Aydın
Department of Pediatrics, Research and Training Hospital of
Sakarya University, Turkey
*Corresponding author: Öner Özdemir, Department of
Pediatrics, Faculty of Medicine, Research and Training
Hospital of Sakarya University, Adnan Menderes Cad, Sağlık
Sok. No: 195, Adapazarı, Sakarya, Turkey, Tel: + 90-(264)
-444 54 00; Fax: +90-(264) -275 91 92; Email:
Received: February 03, 2016 | Published: February 17,
Case3: 7-year-old male was diagnosed with hyper
immunoglobulin M syndrome 5 years ago with complaints of
recurrent fever until 6 month-year-old. He was treated with IVIG
every 3-4 weeks according to his Ig levels and clinical evaluations.
He weighs at 19.5 kilograms and was taking 10g IVIG every 2-3
weeks. For 2 months he has been treated with 5g SCIG per week.
First 8 doses were given in hospital under medical supervision
until his mother learned the procedure. In fourth dose, mild local
reactions including swelling, redness, and burning sensation were
reported at the infusion site that disappeared within 4-6 hours.
His clinic, lung symptoms and serum IgG levels got better and
his prophylactic therapies with TMP/SMX and budesonide were
Conclusion: Our 3 patients tolerated subcutaneous use of
intravenous preparation very well. We observed mild local skin
reactions but there weren’t any systemic complications. All of our
patients’ clinical symptoms, spirometric evaluations and serum Ig
levels got better after SCIG. Our clinical experience showed that
subcutaneous use of same preparation is safer, more effective and
has fewer side effects than intravenous utilization.
Citation: Özdemir Ö, Bingöl-Aydın D (2016) Our Subcutaneous Immunoglobulin Replacement Therapy
Experience with Intravenous Preparation. MOJ Immunol 3(2): 00074. DOI: 10.15406/moji.2016.03.00074