12 International Symposium for Therapeutic Ultrasound

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th
12 International Symposium for
Therapeutic Ultrasound
Heidelberg, Germany
June 10-13, 2012
Preliminary Program
Oral Presentations
Page 1 of 28
Sonothrombolysis
Sunday - June 10, 2012
The clinical challenge and road to translation
Chairs:
13:00
Is there a need for sonothrombolysis in stroke treatment?
M. Hennerici
Neurology Department, Universitätsmedizin Mannheim, University of Heidelberg, Germany
13:20
The potential of ultrasound-accelerated lysis in treating coronary heart disease.
T. Porter
University of Nebraska Medical Center, Omaha, Nebraska, United States
In vitro investigations
13:40
Factors influencing clot lysis with microbubbles and ultrasound
1
M. Borrelli
(1) University of Arkansas for Medical Sciences, Radiology, Little Rock, United States,
14:00
Investigating the interaction between acoustically stimulated microbubbles and
fibrin clots
1
2
1
A-371
1
C. Acconcia , B. Leung , K. Hynynen , D. Goertz
(1) University of Toronto, Medical Biophysics, Toronto, Canada, (2) Sunnybrook Health
Sciences Centre, Toronto, Canada
14:10
A new clot formation protocol for standardized in-vitro investigations of
sonothrombolysis
1
1
1
2
3
A-263
4
F. Roessler , A. Teichert , M. Ohlrich , J.H. Marxsen , F. Stellmacher , G. Seidel
(1) Universitätsklinik Schleswig-Holstein, Neurologie, Lübeck, Germany, (2) Universitätsklinik
Schleswig-Holstein, Internal Medicine, Haematology, Lübeck, Germany, (3)
Forschungszentrum Borstel, Pathologie, Borstel, Germany, (4) Asklepios Klinik Nord Heidberg,
Neurologie, Hamburg, Germany
14:20
Clot dissolution is better with ultrasound assisted thrombolysis for fresh clots with
higher cholesterol content
1
2
3
A-124
2
Y. Zhou , V.K. Sharma , K.S. Murugappan , A. Ahmad
(1) Nanyang Technological University, Mechanical and Aerospace Engineering, Singapore,
Singapore, (2) National University Hospital, Singapore, (3) Nanyang Technological University,
Singapore
14:30
Transcranial Measurements of the Acoustic Field produced by a
Low Frequency Focused Ultrasound System
Arne H. Voie*, David J. Fisher*, Golnaz Ahadi*, Thilo Hölscher*
*Brain Ultrasound Research Laboratory (BURL), University of California San Diego
Page 2 of 28
A-451
Preclinical results
Chairs:
15:30
Successful Microbubble Sonothrombolysis without tPA in a Rabbit Stroke Model
1
1
1
1
2
3
A-200
1
W.C. Culp , R. Flores , A. Brown , J. Lowery , P. Roberson , L. Hennings , S. Woods , J.
1
4
1
1
Hatton , B. Culp , R. Skinner , M. Borrelli
(1) University of Arkansas for Medical Sciences, Radiology, Little Rock , AR, United States, (2)
University of Arkansas for Medical Sciences, Biostatistics, Little Rock , AR, United States, (3)
University of Arkansas for Medical Sciences, Pathology, Little Rock , AR, United States, (4)
University of Arkansas for Medical Sciences, Cardiology, Little Rock , AR, United States
15:50
Transcranial High Intensity Focused Ultrasound For Sonothrombolysis Using the
ExAblate™ 4000 headsystem: In Vitro and In Vivo Results
A-450
Thilo Hölscher*, Golnaz Ahadi*, David J. Fisher*, Arne H. Voie*
*Brain Ultrasound Research Laboratory (BURL), University of California San Diego, USA
16:00
A-404
The effect of compositional properties of thrombus on ultrasound-mediated
thrombolysis in an ex vivo carotid perfusion model
1
2
1
3
1
J. Sutton , N. Ivancevich , S. Perrin Jr. , D. Vela , C. Holland
(1) University of Cincinnati, Biomedical Engineering, Cincinnati, OH, United States, (2) Siemens
Medical Solutions, Issaquah, WA, United States, (3) Texas Heart Institute, Cardiovascular
Pathology, Houston, TX, United States
16:10
1
1
1
1
1
A. Burgess , Y. Huang , A.C. Waspe , M. Ganguly , D.E. Goertz , K. Hynynen
(1) Sunnybrook Research Institute, Physical Sciences, Toronto, Canada
16:20
A-166
High Intensity Focused Ultrasound (HIFU) Treatment of Acute Stroke
1
A-455
Sonothrombolysis in a new mouse model of embolic stroke
E. Handwerker, A. Alonso, J. Jenne, S. Meairs
University of Heidelberg, Department of Neurology, Mannheim, Germany
16:30
A-413
Transcranial MR Guided Focused Ultrasound Treatment of ICH
1
2
3
4
5
6
3
S. Monteith , S. Harnof , N. Kassell , M. Wintermark , E. Zadicario , B. Lopes , J. Snell , M.
3
1
Eames , J. Sheehan
(1) University of Virginia, Dept of Neurosurgery, Charlottesville, Virginia, United States, (2)
Department of Neurosurgery, Sheba Medical Center, Tel Aviv, Israel, (3) Focused Ultrasound
Surgery Foundation, Charlottesville, Virginia, United States, (4) University of Virginia,
Department of Neuroradiology, United States, (5) InSightec, Haifa, Israel, (6) University of
Virginia, Dept of Neuropathology, Charlottesville, Virginia, United States
Page 3 of 28
Clinical Studies of Sonothrombolysis
Chairs: A. Alexandrov
16:40
A meta-analysis of clinical trials of sonothrombolysis in ischemic stroke
F. Perren
Department of Neurology, University Hospital of Geneva, Geneva, Switzerland
17:00
Towards a routine application for treatment of stroke with ultrasound
C. Molina
Neurology Department, Vall d'Hebron University Hospital, Barcelona, Spain
17:10
A-460
Feasibility of MR perfusion imaging during thrombolysis in acute stroke
Matthias Günther*, Johannes Gregori*, Martin Griebe, Christian Sick, Johannes SauterServaes, Marc Wolf, Philipp Eisele, Kristina Szabo, Michael G. Hennerici, Rolf Kern
Department of Neurology, Universitätsmedizin Mannheim, University of Heidelberg,
Mannheim, Germany;
*Fraunhofer MEVIS - Institute for Medical Image Computing, Bremen, Germany
17:20
Sonothrombolysis for Patients with Contraindication to Alteplase (rt-PA): Results
from an ongoing Registry
1
1
A-372
1
J. Eggers , M. Ohlrich , F. Roessler
(1) University Hospital of Lübeck, Neurology, Lübeck, Germany
17:30
Risk reduction of brain infarction during carotid endarterectomy or stenting using
sonolysis. A prospective randomized study.
1
1
1
2
3
3
3
M. Kuliha , D. Skoloudik , M. Roubec , R. Herzig , V. Procházka , T. Jonszta , J. Krajca , D.
3
4
4
5
Czerny , T. Hrbac , D. Otahal , K. Langova
(1) University Hospital Ostrava, Neurology, Ostrava, Czech Republic, (2) University Hospital
and Palacky University Olomouc, Neurology, Olomouc, Czech Republic, (3) University Hospital
Ostrava, Radiology, Ostrava, Czech Republic, (4) University Hospital Ostrava, Neurosurgery,
Ostrava, Czech Republic, (5) University Hospital and Palacky University Olomouc, Biophysics,
Olomouc, Czech Republic
17:40
CLOTBUSTER: a phase III randomized blinded multi-national clinical trial of
sonothrombolysis for acute ischemic stroke
A. Alexandrov
Comprehensive Stroke Center, University of Alabama Hospital, Birmingham, Alabama, United
States
Page 4 of 28
A-197
12th International Symposium for
Therapeutic Ultrasound
Monday - June 11, 2012
Sonoporation
Chairs:
8:00
A-158
Ultrasound-mediated Gene Delivery to Skeletal Muscles in vivo
1
2
2
1
P. Sanches , M. Mühlmeister , K. Tiemann , H. Grüll
(1) Eindhoven University of Technology, Biomedical Engineering, Eindhoven, Netherlands, (2)
University Hospital Muenster, Department of Cardiology and Angiology, Muenster, Germany
8:10
High intensity ultrasound in microfluidic for cell lysis and sonoporation
1
1
2
A-194
3
S.-W. Ohl , T. Tandiono , D. Ow , C.-D. Ohl
(1) Institute of High Performance Computing, Singapore, Singapore, (2) Bioprocessing
Technology Institute, Singapore, Singapore, (3) Nanyang Technological University, School of
Physical and Mathematical Sciences, Singapore, Singapore
8:20
Characteristics of Sonoporated Cells after Resealing: Reduced Cell Size and Increased A-235
Granularity
1
2
2
1
X. Chen , W.H. Sit , J.M.F. Wan , A.C.H. Yu
(1) The University of Hong Kong, Medical Engineering Program, Pokfulam, Hong Kong, (2) The
University of Hong Kong, School of Biological Sciences, Pokfulam, Hong Kong
8:30
Prolonging the transgene expression by ultrasound-mediated gene delivery
combined with PEI nanoparticles: an in vitro and in vivo study
1
1
A-163
1
C.-W. Lo , J.-L. Lee , W.-S. Chen
(1) National Taiwan University Hospital, Department of Physical Medicine and Rehabilitation,
Taipei, Taiwan
8:40
A-177
Controlled jetting from collapsing cavities exposed to HIFU
1
2
3
1
1
1
B. Gerold , P. Glynne-Jones , J. Grinfeld , S. Cochran , A. Melzer , P. Prentice
(1) University of Dundee, IMSaT, Dundee, United Kingdom, (2) University of Southampton,
Southampton, United Kingdom, (3) Insightec Ltd., Haifa, Israel
Page 5 of 28
Ultrasound-induced neuromodulation
Chairs: S.S. Yoo
8:50
Induction of Animal Motor Behaviors By FUS-mediated Functional Neuromodulation
1
A-165
1
S.S. Yoo , H. Kim
(1) Harvard Medical School / Brigham and Women's Hospital, Radiology, Boston, United States
9:10
Ultrasonic Neuromodulation in a rat model : in vivo investigation of an acoustic
threshold for motor response
1
1
1
1
1
1
Y. Younan , T. Deffieux , B. Larrat , A. Souilah , M. Fink , J.-F. Aubry , M. Tanter
(1) Institut Langevin, Paris, France
9:20
1
Molecular Imaging Evidence on Pulsed FUS-mediated Neuromodulation: A
Preliminary Study
1
1
1
1
2
A-374
A-164
1
H. Kim , M.-A. Park , S. Wang , A. Chiu , S. Park , S.-S. Yoo
(1) Brigham & Women's Hospital, Radiology, Boston, United States, (2) Korea University,
Mechanical Engineering, Seoul, South Korea
9:30
Ultrasound as a Regulator of Neuronal Morphology: Impact on Differentiated
Neuro-2a Cells
1
1
2
2
A-233
1
Y. Hu , W. Zhong , W.H. Sit , J.M.F. Wan , A.C.H. Yu
(1) The University of Hong Kong, Medical Engineering Program, Pokfulam, Hong Kong, (2) The
University of Hong Kong, School of Biological Sciences, Pokfulam, Hong Kong
9:40
A-359
Ultrasound Induced In-Vivo Neurostimulation
1
2
2
3
R. King , J. Brown , W. Newsome , K. Butts Pauly
(1) Stanford University, Bioengineering, Stanford, United States, (2) Stanford University,
Neuroscience, Stanford, United States, (3) Stanford University, Radiology, Stanford, United
States
9:50
Vagus Nerve Modulation Using Focused Ultrasound
1
2
2
2
A-300
1
R. González , M. Ward , G. Albors , P. Irazoqui , E. Juan
(1) University of Puerto Rico - Mayagüez, Electrical Engineering, Mayagüez, Puerto Rico, (2)
Purdue University, Weldon School of Biomedical Engineering, West Lafayette, United States
Ultrasound-Induced Blood-Brain Barrier Opening
Chairs: K. Hynynen and G. Fricker
10:30
Towards Clinical Applications of BBB-opening with ultrasound
1
K. Hynynen
(1) University of Toronto, Medical Biophysics, Toronto, Canada
10:50
Non-Human Primate Skull Effects on the In-Vivo Study of the Mechanism of the
FUS-Induced Blood-Brain Barrier Opening
1
1
1
1
S.-Y. Wu , Y.-S. Tung , F. Marquet , E. Konofagou
Columbia University, Biomedical Engineering, New York City, United States
Page 6 of 28
A-325
11:00
Neuronavigation-Guided Focused Ultrasound-Induced Blood-Brain Barrier Opening
in Swine
1
2
2
A-328
2
H.-L. Liu , H.-C. Tsai , Y.-J. Lu , K.-C. Wei
(1) Chang Gung University, Department of Electrical Engineering, Kweishan,Taoyuan, Taiwan,
(2) Chang-Gung University and Memorial Hospital, Department of Neurosurgery, Taoyuan,
Taiwan
11:10
Blood-Brain Barrier Opening by Unfocused Ultrasound: In Vivo Toxicological Studies
in Normal Canine Brain
1
1
1
1
2
3
A-314
4
C. Horodyckid , M. Canney , K. Beccaria , A. Vignot , P. Merlet , A. Prigent , C. Lafon , J.-Y.
4
5
Chapelon , A. Carpentier
(1) Carthéra, Hôpital de la Pitié Salpêtrière, Paris, F-75013, France, (2) CEA, IR4M, SHFJ,,
Orsay, F-91400, France, (3) ICM, UMRS975, Hôpital de la Pitié Salpêtrière, Paris, F-75013,
France, (4) INSERM, U1032, LabTau, Lyon, F-69003, France, (5) Assistance-Publique Hôpitaux
de Paris, Hôpital de la Pitié Salpêtrière, Service de Neurochirurgie, Paris, F-75013, France
11:20
Modelling the effect of drug size and injection schemes on drug delivery to the
brain in the event of blood-brain barrier disruption
1
2
2
A-303
1
T. Nhan , A. Burgess , E.E. Cho , K. Hynynen
(1) University of Toronto, Medical Biophysics, Toronto, Canada, (2) Sunnybrook Research
Institute, Physical Sciences, Toronto, Canada
11:30
1
2
2
2
1
1
A. Alonso , E. Reinz , B. Leuchs , J. Kleinschmidt , M. Fatar , M.G. Hennerici , S. Meairs
(1) Department of Neurology, Universitätsmedizin Mannheim, University of Heidelberg,
Mannheim, Germany
(2) German Cancer Research Center, Heidelberg, Germany
11:40
A-417
Efficient expression of AAV2/1-transgenes into the rat brain after ultrasoundinduced BBB opening
1
Controlled blood-brain barrier disruption for safe and efficacious pharmacological
therapies of the brain
1
2
1
A-222
1
C. Arvanitis , M. Livingstone , N. Vykhodtseva , N. McDannold
(1) Harvard Medical School, Radiology, Boston, United States, (2) Harvard Medical School,
Neurobiology, Boston, United States
11:50
Targeting Accuracy and Closing Timeline of the Microbubble-Enhanced Focused
Ultrasound Blood-Brain Barrier Opening in Non-Human Primates
1
1
2
2
A-387
1
F. Marquet , Y.-S. Tung , T. Teichert , V. Ferrera , E. Konofagou
(1) Columbia University, Biomedical Engineering, New York, United States, (2) Columbia
University, Neuroscience, New York, United States
12:00
Focused Ultrasound-Mediated Delivery of 80 nm Sized Liposomes into the Mouse
Brain
1
2
3
3
2
Z. Kovacs , P. Luciani , B. Werner , E. Martin-Fiori , J.-C. Leroux
(1) University Children's Hospital Zurich, Children's Research Center, Zurich, Switzerland, (2)
Institute of Pharmaceutical Sciences, ETH Zurich, Drug Formulation & Delivery, Zurich,
Switzerland, (3) University Children's Hospital Zurich, Children's Research Center, Center for
MR-Research, Zurich, Switzerland
Page 7 of 28
A-313
Shaping the future of MR-guided focused ultrasound
Chairs:
14:00
The Focused Ultrasound Surgery Foundation
N. Kassell
University of Virginia, Neurosurgery, Charlottesville, United States
14:15
SonoDrugs – A European Union Project on ultrasound-assisted drug delivery
H. Gruell
Eindhoven University of Technology, Netherlands
14:30
FUSIMO – An initiative of the European Union
T. Preusser
Fraunhofer MEVIS, Bremen, Germany
14:45
Nanoporation – A network for MRgFUS cancer treatment
A. Melzer
University of Dundee, Dundee, United Kingdom
Imaging
Chairs: M. Günther
15:30
Problems and solutions associated with visual motion tracking using ultrasound
images
A-227
N. Koizumi, J.Seo, D.Lee, A.Nomiya, A.Ishikawa, K.Yoshinaka, N.Sugita, Y.Matsumoto,
Y.Homma, and M.Mitsuishi
The Univ. of Tokyo, School of Engineering, Tokyo, Japan
15:40
A-243
The use of Gd-DTPA prior MR-HIFU ablation treatment
1
2
2
N.M. Hijnen , A. Elevelt , H. Grüll
(1) Eindhoven University of Technology, Biomedical Engineering, Eindhoven, Netherlands, (2)
Philips Research, Bio-Molecular Engineering, Eindhoven, Netherlands
15:50
Motion compensated detection of focal coagulation induced by HIFU using
correlation between RF ultrasonic images during treatment
1
1
2
1
A-346
2
R. Matsuzawa , T. Shishitani , S. Sasaki , S. Yoshizawa , S.-i. Umemura
(1) Tohoku University, Gaduate School of Engineering, Sendai, Japan, (2) Tohoku University,
Gaduate School of Biomedical Engineering, Sendai, Japan
16:00
Real-Time High-Intensity Focused Ultrasound Beam Path Visualization Using
Ultrasound Imaging
1
2
3
4
4
J.H. Song , J.H. Cha , J.H. Chang , T.-k. Song , Y. Yoo
(1) Sogang University, Medical Solution Institute, Seoul, South Korea, (2) Sogang University,
Interdisciplinary Program of Integrated Biotechnology, Seoul, South Korea, (3) Sogang
University, Sogang Institues of Advanced Technology, Seoul, South Korea, (4) Sogang
University, Department of Electronic Engineering, Seoul, South Korea
Page 8 of 28
A-104
16:10
A-289
3D Spin-Echo Acoustic Radiation Force Impulse Imaging in Ex Vivo Porcine
1
2
2
2
J. de Bever , N. Todd , M. Diakite , D. Parker
(1) University of Utah, School of Computing, Salt Lake City, United States, (2) University of
Utah, Utah Center for Advanced Imaging Research, Salt Lake City, United States
Microbubbles and Nanotechnology
Chairs: N. de Jong and E. Stride
16:20
The future of microbubbles in applications of therapeutic ultrasound
N. de Jong
ErasmusMC, Thoraxcenter, Rotterdam, Netherlands
16:40
A-339
Characteristics of liposome-loaded microbubbles for therapeutic use
1
1
1
1
2
2
2
N. deJong , Y. Luan , T. Faez , T. van der Steen , B. Geers , H. Dewitte , I. Lentacker , E.
3
3
Gelderblom , M. Versluis
(1) ErasmusMC, Thoraxcenter, Rotterdam, Netherlands, (2) Ghent University, Nanomedicine,
Ghent, Belgium, (3) University of Twente, Physics of Fluids, Enschede, Netherlands
16:40
Interaction of tandem bubbles with individual cells patterned in a microfluidic
channel
1
1
1
1
A-326
1
F. Yuan , X. Huang , G. Sankin , N. Simmons , P. Zhong
(1) Duke University, Mechanical Engineering and Materials Science, Durham, United States
16:50
Multi-functionalized microballoons for three modality contrast imaging:
ultrasound, MRI and SPECT.
1
1
1
2
A-249
3
D. Grishenkov , L.-Å. Brodin , H. Hebert , G. Paradossi , T.B. Brismar
(1) Royal Institute of Technology, KTH, School of Technology and Health, Huddinge, Sweden,
(2) Università di Roma Tor Vergata, Dipartimento di Scienze e Tecnologie Chimiche, Rome,
Italy, (3) Karolinska University Hospital, CLINTEC, Huddinge, Sweden
17:00
Experimental studies on effects of cavitation and boiling bubbles played on the
hyperecho appearance on B-mode ultrasound images
1
1
1
1
1
A-291
1
F. Li , H. Ai , M. Zhong , H. Yi , Q. Wang , Z. Wang
(1) Chongqing Medical University, Chongqing, China
17:10
Photo-Assisted HIFU Therapy with Optically Vaporizable Perfluorocarbon Droplets
1
A-228
1
R. Asami , K.-i. Kawabata
(1) Central Research Laboratory, Hitachi, Ltd., Tokyo, Japan
17:20
A-257
Retention of magnetic microbubbles within a flow phantom
1
2
3
2
4
1
J. OWEN , B. Zhou , N. Hayotte , M.-X. Tang , R. Eckersley , E. Stride
(1) University of Oxford, Institute of Biomedical Engineering, OXFORD, United Kingdom, (2)
Imperial College London, Department of Bioengineering, London, United Kingdom, (3)
University College London, Department of Mechanical Engineering, London, United Kingdom,
(4) Imperial College London, Imaging Sciences Department, London, United Kingdom
Page 9 of 28
17:30
Effect of ultrasonic parameters on microbubble concentration during irradiation
1
1
2
3
3
A-329
3
Y. Zhang , T. Azuma , K. Yoshinaka , A. Sasaki , S. Takagi , Y. Matsumoto
(1) The University of Tokyo, Department of Bioengineering, Tokyo, Japan, (2) The National
Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan, (3) The
University of Tokyo, Department of Mechanical Engineering, Tokyo, Japan
17:40
An Experimental Study on the Stiffness of Size-Isolated Microbubbles Used for
Blood-Brain Barrier Opening
1
1
1
1
A-360
1
C. Chen , S.-Y. Wu , J. Finan , B. Morrison III , E. Konofagou
(1) Columbia University, Department of Biomedical Engineering, New York, United States
17:50
Enhancement of HIFU ablation by use of cavitation-promoting sonosensitive
nanoparticles
1
1
A-356
1
N. Hockham , S.J. Wagstaffe , C.C. Coussios
(1) University of Oxford, Institute of Biomedical Engineering, Oxford, United Kingdom
18:00
Numerical study on microbubble-enhanced heating for various parameters in EUSFUS
1
2
3
A-113
3
K. Okita , M. Maezawa , S. Takagi , Y. Matsumoto
(1) Nihon University, College of Industrial Technology, Department of Mechanical Engineering,
Chiba, Japan, (2) OLYMPUS, Tokyo, Japan, (3) The University of Tokyo, School of Engineering,
Department of Mechanical Engineering, Tokyo, Japan
18:10
Effects of gold nanoparticles on the stability and non-linear response of
phospholipid microbubbles
1
2
1
2
1
G. Mohamedi , M. Azmin , P. Rademeyer , M. Edirisinghe , E. Stride
(1) University of Oxford, Department of Engineering Science, Oxford, United Kingdom, (2)
University College London, Mechanical Engineering, London, United Kingdom
Page 10 of 28
A-204
Physical Studies
Chairs:
15:30
A-382
Tissue Characterisation for HIFU
1
1
1
J. Civale , I. Rivens , G. ter Haar
(1) Institute of Cancer Research, Sutton, United Kingdom
15:40
Ultrasound streaming and bubble field in the configuration of a standing wave
ultrasound generator designed for adherent cell transfection.
1
1
1
1
J.-C. Bera , P. Labelle , C. Vanbelle , J.-L. Mestas , C. Inserra
(1) INSERM, U1032, Lyon, France
15:50
1
Mechanistic assessment of the role of stress waves and cavitation in stone
fragmentation during shock wave lithotripsy
1
1
1
A-133
A-112
1
J. Lautz , G. Sankin , J. Kleinhenz , P. Zhong
(1) Duke University, Mechanical Engineering and Materials Science, Durham, United States
16:00
Tunable time-reversal cavity for high-amplitude ultrasonic pulse generation.
1
1
1
A-278
1
B. Arnal , M. Pernot , M. Fink , M. Tanter
(1) Institut Langevin, ESPCI ParisTech, CNRS UMR 7587, INSERM ERL U979, Université Paris
Diderot, Paris, France
16:10
Laser Sheet Optical Methods For The Fast Rise Time Diagnostics Of Millisecond
Heating From HIFU
1
1
A-411
2
G.F. Oweis , M. Al-Qraini , M.S. Canney
(1) American University of Beirut, Lebanon, (2) University of Washington, Center for Industrial
and Medical Ultrasound, Applied Physics Laboratory, Seattle, United States
16:20
A-190
Ultra-high speed observation of laser-nucleated acoustic cavitation
1
2
2
3
1
1
1
B. Gerold , J. Grinfeld , O. Prus , Y. Medan , S. Cochran , A. Melzer , P. Prentice
(1) University of Dundee, IMSaT, Dundee, United Kingdom, (2) Insightec Ltd., Haifa, Israel, (3)
Technion, Biomedical Engineering, Haifa, Israel
Page 11 of 28
Transducers and devices
Chairs:
16:30
A-357
15-mm Diameter Dual Frequency Imaging and Therapeutic Transducer Using an
Acoustic Band-pass Filter for Endoscopic Surgery
1
2
2
T. Azuma , H. Hajime Kenmotsu , M. Hashidume
(1) The University of Tokyo, Faculty of Engineering, Tokyo, Japan, (2) Kyushu University,
Facaulty of Medicine, Fukuoka, Japan
16:40
Driving Frequency Control of Individual Channel on a Phased Array HIFU Transducer
for Focal Resolution Improvement
1
1
1
A-159
1
K. SON , D. KIM , K. KANG , M. KIM
(1) ALPINION MEDICAL SYSTEMS, New Business Development, Seoul, South Korea
16:50
A-271
Electrical power measurement of complex loads at MHz frequencies
1
1
E. Martin , A. Shaw
(1) National Physical Laboratory, Teddington, Middlesex, United Kingdom
17:00
A-321
High Intensity Ultrasound Transducer for Gene Transfection
1
1
2
3
2
K.P. Morrison , G.W. Keilman , M.L. Noble , A.A. Brayman , C.H. Miao
(1) Sonic Concepts, Inc., Bothell, United States, (2) Seattle Children's Research Institute,
Seattle, United States, (3) University of Washington, Seattle, United States
17:10
A-323
Mechanical focusing effect on CMUT using concave structure
1
2
1
1
3
1
4
H.-S. Yoon , C. Chang , K.-K. Park , T. Carver , D. Stephens , A. Nikoozadeh , K. Butts-Pauly ,
1
P. Khuri-Yakub
(1) Stanford University, E.L.Ginzton Lab, Stanford, United States, (2) R&D Center, Canon USA,
Inc., United States, (3) University of California, Davis, United States, (4) Stanford University,
Radiology, Stanford, United States
17:20
New Piezocrystal Material in the Development of a 96-element Array Transducer
for MR-guided Focused Ultrasound Surgery
1
2
1
A-283
1
Z. Qiu , Z. Huang , C. Démoré , S. Cochran
(1) University of Dundee, Institute for Medical Science and Technology (IMSaT), Dundee,
United Kingdom, (2) University of Dundee, School of Physics, Mathematics and Engineering,
Dundee, United Kingdom
17:30
Nonlinear Acoustic Holography for Therapeutic Source Characterization
1
1
2
A-229
1
S. Tsysar , V. Khokhlova , W. Kreider , O. Sapozhnikov
(1) Moscow State University, Physics Faculty, Department of Acoustics, Moscow, Russian
Federation, (2) University of Washington, Center for Industrial and Medical Ultrasound,
Applied Physics Laboratory, Seattle, United States
17:40
On the reliability of voltage and power as input parameters for the characterization
of high power ultrasound applications
1
1
J. Haller , V. Wilkens
(1) Physikalisch-Technische Bundesanstalt, 1.62 - Ultrasound, Braunschweig, Germany
Page 12 of 28
A-245
17:50
Optimal Patterns for Sequentially Multiple Focusing in High Intensity Focused
Ultrasound and Their Application to Thermal Dose
1
1
1
1
A-126
1
M.-B. Shim , H.-K. Lee , H.-T. Lee , J.-H. Park , M.-S. Ahn
(1) Samsung Electronics Co. Ltd., Samsung Advanced Institute of Technology, Youngin-City,
South Korea
18:00
Power measurement up to 10 MHz using the buoyancy change method
1
A-250
1
A. Shaw , S. Rajagopal
(1) National Physical Laboratory, Teddington, United Kingdom
18:10
A-380
Rapid Optimised Phased Array Transducer Design
1
1
1
1
I. Rivens , R. Symonds-Taylor , J. Civale , G. ter Haar
(1) Institute of Cancer Research : Royal Marsden NHS Foundation Trust, Joint Department of
Physics, Sutton, United Kingdom
18:20
Uterine fibroid ablation using a flat phased array: a simulation analysis of patient
safety
1
A-384
1
N. Ellens , K. Hynynen
(1) Sunnybrook Research Institute, Imaging Research, Toronto, Canada
18:30
Toroidal Transducer With Two Large Focal Zones For Increasing The Coagulated
Volume
1
1
1
1
J. VINCENOT , D. MELODELIMA , A. VIGNOT , F. CHAVRIER , J.-Y. CHAPELON
(1) Inserm, U1032 ; Université de Lyon, Lyon, F-69003, France
Page 13 of 28
1
A-210
12th International Symposium for
Therapeutic Ultrasound
Tuesday - June 12, 2012
Drug delivery I
Chairs:
8:00
Ultrasound-mediated drug delivery: which drug carrier and ultrasound parameters
are likely to translate to clinical practice?
A-153
1
N. Rapoport
(1) University of Utah, Bioengineering, Salt Lake City, United States
8:20
Dynamics of Blood-Brain Barrier Permeability Induced by MRI-Guided Focused
Ultrasound and Correlation with Doxorubicin Delivery
1
1
1
1
1
J. Park , Y.-Z. Zhang , C. Power , N. Vykhodtseva , F. Jolesz , N. McDannold
(1) Harvard Medical School, Radiology, Boston, United States
8:30
1
Pulsed HIFU Enhanced Penetration of Fluorescent Molecules into Pancreas Tumors
In Vivo
1
2
2
3
4
A-317
2
A-290
5
Y.-N. Wang , T. Khokhlova , H. Chen , M. Dreher , N. Farr , S. D'Andrea , S. Hingorani , J.H.
2
Hwang
(1) University of Washington, Applied Physics Laboratory, Seattle, United States, (2) University
of Washington, Department of Medicine, Seattle, United States, (3) National Instituties of
Health, Bethesda, United States, (4) University of Washington, Department of Bioengineering,
Seattle, United States, (5) Fred Hutchinson Cancer Research Center, Seattle, United States
8:40
Molecular Transport Mechanisms in Ultrasound Assisted Transdermal Drug and
Vaccine Delivery; A Mechanistic Study
1
1
A-246
1
S. Bhatnagar , C.C. Coussios , H. Schiffter
(1) University of Oxford, Institute of Biomedical Engineering, Oxford, United Kingdom
8:50
Improved intratumoral distribution of temperature sensitive liposomes and
doxorubicin after combined hyperthermia and ablation treatment
1
1
A-248
2
N.M. Hijnen , M. de Smet , H. Grüll
(1) Eindhoven University of Technology, Biomedical Engineering, Eindhoven, Netherlands, (2)
Philips Research, Bio-Molecular Engineering, Eindhoven, Netherlands
9:00
Customized and Noninvasive Trancutaneous Drug Transport: Will Ultrasound
Deliver?
1
1
1
1
1
1
1
P.A. Lewin , A. Nguyen , S.P. Wrenn , Y. Sunny , C. Bawiec , J. Samuels , L. Zubkow , E.S.
1
Papazoglou
(1) Drexel University, Biomed, Philadelphia, United States
Page 14 of 28
A-285
9:10
The Effects of Extracorporeal Shockwave Mediated Transdermal Drug Delivery in
Nerve of Rats Tail
1
A-109
1
J.-J. Luh , W.-T. Huang
(1) National Taiwan University, School and Graduate Institute of Physical Therapy, Taipei,
Taiwan
9:20
1
2
2
2
1
O. Couture , A. Urban , A. Bretagne , L. Martinez , P. Tabeling , M. Tanter
(1) CNRS, Paris, France, (2) ESPCI, Paris, France, (3) INSERM, Paris, France
9:30
A-184
In-vivo targeted delivery of large payloads with an ultrasound clinical scanner
3
A-123
Noninvasive and Temporary Blood Retinal Barrier Disruption via MR-Guided
Focused Ultrasound For Targeted Ocular Drug Delivery
1
2
1
1
1
1
1
J. Park , J. Akula , C. Arvanitis , Y.-Z. Zhang , C. Power , N. Vykhodtseva , N. McDannold
(1) Harvard Medical School, Radiology, Boston, United States, (2) Harvard Medical School,
Ophthalmology, Boston, United States
9:40
Acoustic droplet-hydrogel composite for the ultrasonic release of basic fibroblast
growth factor
1
2
3
4
1
A-114
2
M. Fabiilli , C. Wilson , F. Martin-Saavedra , F. Padilla , J.B. Fowlkes , R. Franceschi
(1) University of Michigan, Radiology, Ann Arbor, United States, (2) University of Michigan,
Dentistry, Ann Arbor, United States, (3) Hospital Universitario La Paz-IdiPAZ & CIBER-BBN,
Madrid, Spain, (4) Inserm Unit 1032, Lab of Therapeutic Applications of Ultrasound, Lyon,
France
9:50
Ultrasound-induced oxygen and drug delivery by a dodecafluoropentane
nanoemulsion
1
1
1
2
1
M. Borrelli , E. Hamilton , A. Brown , R. Skinner , W. Culp
(1) University of Arkansas for Medical Sciences, Radiology, Little Rock, United States, (2)
University of Arkansas for Medical Sciences, Neuroscience, Little Rock, United States
Page 15 of 28
A-343
MR-guided focused ultrasound – Preclinical studies
Chairs:
10:30
MR-guided Interstitial Thermal Ablation in the Brain Using a Multi-Element
Ultrasound Device: In Vivo Testing in a Canine Model
1
2
2
3
3
A-231
3
M. Canney , K. Beccaria , C. Horodyckid , R. Souchon , F. Chavrier , C. Lafon , J.-Y.
3
2
Chapelon , A. Carpentier
(1) INSERM U1032/CarThera, Lyon, France, (2) Pitie-Salpetriere Hospital, Assistance Publique Hôpitaux de Paris, Neurosurgery Department, Paris, France, (3) Inserm, U1032, LabTau, Lyon,
France
10:40
MRI-controlled Interstitial Ultrasound Brain Therapy: an initial in-vivo study
1
2
3
4
A-350
3
W.A. N'DJIN , M. BURTNYK , N. LIPSMAN , M. BRONSKILL , M. SCHWARTZ , W.
5
4
KUCHARCZYK , R. CHOPRA
(1) Sunnybrook Research Institute, Imaging Research, Toronto, ON, Canada, (2) Sunnybrook
Research Institute, Imaging Research, Department of Medical Biophysics, University of
Toronto, Department of Medical Imaging, University Health Network and the University of
Toronto, Toronto, ON, Canada, (3) Division of Neurosurgery, University of Toronto, Toronto,
Canada, (4) Sunnybrook Research Institute, Imaging Research, Department of Medical
Biophysics, University of Toronto, Toronto, ON, Canada, (5) Department of Medical Imaging,
University Health Network and the University of Toronto, Toronto, Canada
10:50
Treatment of localized abscesses induced by methicillin-resistant Staphylococcus
aureus (MRSA) using MRgFUS: First in vivo results
1
1
2
3
A-168
1
B. Rieck , L. Curiel , C. Mougenot , K. Zhang , S. Pichardo
(1) Thunder Bay Regional Research Institute, Image-guided Interventions, Thunder Bay,
Canada, (2) Philips Healthcare, Canada, (3) Faculty of Medicine, University of Calgary,
Department of Pathology and Laboratory Medicine, Calgary, Canada
11:00
MRI-Guided Drug Delivery to Pancreatic Cancer using Ultrasound-Activated
Perfluorocarbon Nanoemulsions (Research in Progress)
1
2
2
1
3
3
A-160
1
N. Rapoport , A. Payne , N. Todd , C. Dillon , J. Shea , C. Scaife , R. Gupta
(1) University of Utah, Bioengineering, Salt Lake City, United States, (2) University of Utah,
Center for Advanced Imaging Research, Salt Lake City, United States, (3) University of Utah,
Surgery, Salt Lake City, United States
11:10
Acoustic shielding to avoid unwanted prefocal energy deposition during transcostal
HIFU liver ablation
1
1
1
2
3
4
1
R. Salomir , L. Petrusca , V. Auboiroux , J. Roland , D. Morel , A. Muller , T. Goget , S.
1
1
5
5
1
1
1
Terraz , R. Breguet , S. Brunke , M. Sekins , C. Becker , M. Vargas , M. Viallon
(1) Geneva University Hospital, Radiology Department, Geneve 14, Switzerland, (2) Siemens
HealthCare AG, Erlangen, Germany, (3) Geneva University Hospital, Department of
Anesthesiology, Geneva, Switzerland, (4) Department of Radiology, RMN Unit, Lyon, France,
(5) Siemens Medical Solutions, Washington, United States
Page 16 of 28
A-381
11:20
MR Guided Focused Ultrasound Surgery for Trigeminal Neuralgia - A Cadaveric and
Laboratory Feasibility Study
1
1
2
3
4
2
A-415
2
S. Monteith , J. Sheehan , N. Kassell , M. Wintermark , R. Medel , M. Eames , J. Snell , E.
5
6
4
Zadicario , J.G. Grinfeld , J. Elias
(1) University of Virginia, Dept of Neurosurgery, Charlottesville, Virginia, United States, (2)
Focused Ultrasound Surgery Foundation, Charlottesville, Virginia, United States, (3) University
of Virginia, Department of Neuroradiology, United States, (4) University of Virginia,
Charlottesville, Virginia, United States, (5) InSightec, Haifa, Israel, (6) University, United States
11:30
Effect of respiratory motion on intra-operative liver thermal therapy performed
with a toroidal-shaped HIFU transducer
1
1
1
2
A-353
2
W.A. N'DJIN , D. MELODELIMA , J.-Y. CHAPELON , N. MILLER , J. BAMBER
(1) LabTAU, INSERM U1032, Laboratory of Therapeutic Applications of Ultrasound, University
of Lyon, Lyon Cedex 03, France, (2) Royal Marsden NHS trust and Institute of Cancer Research,
Sutton, United Kingdom
Monitoring Therapeutic Ultrasound I
Chairs:
13:00
New methods and advanced instrumentation for MR-guidance of extra-corporeal
HIFU treatment in upper abdomen
R. Salomir
Radiology Department, University Hospitals of Geneva, Geneva, Switzerland
13:20
Feasibility of absolute MR thermometry in bone marrow for MR-guided HIFU of
bone metastases
1
1
1
A-107
1
M.K. Lam , M. de Greef , R. Deckers , L.W. Bartels
(1) Image Sciences Institute, UMC Utrecht, Utrecht, Netherlands
13:30
Assessment of HIFU Lesions by Shear-Wave Elastography: Initial In-Vivo Results
1
2
3
1
A-145
1
J. Anquez , J.-M. Corréas , A. Criton , F. Lacoste , S. Yon
(1) Theraclion, Malakoff, France, (2) Necker Hospital, Adult Radiology, Paris, France, (3)
SuperSonic Imagine, France
13:40
Real-time temperature estimation and monitoring of HIFU ablation through a
combined modelling and passive acoustic mapping approach
1
1
A-299
1
C. Jensen , R. Cleveland , C. Coussios
(1) University of Oxford, Institute of Biomedical Engineering, Oxford, United Kingdom
13:50
Tissue acoustic thermometry performance comparison between thermal strain
imaging and a neural network approach for HIFU therapy
1
1
1
1
1
C. Maleke , S.J. Hsu , J.H. Nam , L. Fan , K.M. Sekins
(1) Siemens Healthcare, Ultrasound, Issaquah, United States
Page 17 of 28
A-224
14:00
Real-time organ motion tracking in High Intensity Ultrasound treatment using
sonoelastography: a feasibility study
1
1
2
3
A-310
4
X. Xiao , Z. Huang , A. Melzer , G. Corner , G. Nabi
(1) University of Dundee, Dundee, United Kingdom, (2) Institute for Medical Science and
Technology, Dundee, United Kingdom, (3) Ninewells hospital and medical school, Dundee,
United Kingdom, (4) Ninewells hospital, Department of urology, Dundee, United Kingdom
14:10
In vivo study of the dynamics of Blood Brain Barrier closure after ultrasoundinduced disruption. A quantitative analysis.
1
2
1
3
3
3
A-203
2
B. Larrat , B. Marty , M. Pernot , P. Robert , M. Port , C. Robic , D. Le Bihan , F.
2
1
2
Lethimonnier , M. Tanter , S. Mériaux
(1) Institut Langevin/ESPCI ParisTech/INSERM U979, Paris, France, (2)
CEA/DSV/I2BM/NeuroSpin, Gif sur Yvette, France, (3) Research Division, Guerbet, Aulnay sous
Bois, France
14:20
The Optimization of Amplitude Modulation Frequency for Harmonic Motion
Imaging
1
1
1
2
2
2
A-301
3
R. Aoyagi , H. Nakamura , W. Baba , K. Fujiwara , H. Takeuchi , K. Itani , T. Azuma , K.
4
3
1
1
Yoshinaka , A. Sasaki , S. Takagi , Y. Matsumoto
(1) The University of Tokyo, Mechanical Engineering, Hongo, Bunkyo-ku, Tokyo, Japan, (2)
Hitachi-Aloka Medical, Ltd., Toyko, Japan, (3) The University of Tokyo, Bioengineering, Hongo,
Bunkyo-ku, Tokyo, Japan, (4) The National Institute of Advanced Industrial Science and
Technology, Tsukuba, Japan
14:30
A comparison of Magnetic Resonance, ultrasound and fibre-optic thermometry
during High Intensity Focused ultrasound
1
1
1
A-258
1
V. Bull , J. Civale , I. Rivens , G. ter Haar
(1) Institute of Cancer Research, Joint Department of Physics, Sutton, United Kingdom
14:40
Monitoring the lesion formation during histotripsy treatment using shear wave
imaging
1
1
1
A-292
1
W.-N. Lee , B. Arnal , M. Pernot , M. Tanter
(1) Institut Langevin, ESPCI ParisTech, CNRS, UMR 7587, INSERM, U979, Paris, France
14:50
In Vivo Passive Acoustic Mapping during Cavitation-Enhanced Virotherapy
1
2
2
1
J.J. Choi , R. Carlisle , L. Seymour , C.-C. Coussios
(1) University of Oxford, Department of Engineering Science, Oxford, United Kingdom, (2)
University of Oxford, Department of Clinical Pharmacology, Oxford, United Kingdom
Page 18 of 28
A-340
Monitoring Therapeutic Ultrasound II
Chairs:
15:30
A-208
Dual-Mode Ultrasound Arrays for Image-Guided Targeting of Atheromatous
Plaques
1
2
1
2
1
3
1
J.R. Ballard , A. Casper , D. Liu , A. Haritonova , I. Shehata , M. Troutman , E.S. Ebbini
(1) University of Minnesota, Department of Electrical and Computer Engineering,
Minneapolis, MN, United States, (2) Unviersity of Minnesota, Department of Biomedical
Engineering, Minneapolis, MN, United States, (3) American Preclinical Services, Coon Rapids,
MN, United States
15:40
Large coverage 3D Imaging for visualizing skull surface heating during transcranial
MRgFUS
1
1
1
1
1
1
N. Todd , J. de Bever , S. Almquist , H. Odeen , A. Payne , D. Christensen , D. Parker
(1) University of Utah, Salt Lake City, United States
15:50
1
16:00
1
Ultrasonography-based 2D motion compensated HIFU sonication integrated with
reference-free MR temperature monitoring: a feasibility study ex vivo
1
1
1
1
V. Auboiroux , L. Petrusca , M. Viallon , T. Goget , C. Becker , R. Salomir
(1) University Hospitals of Geneva, Radiology, Geneva, Switzerland
2
2
2
1
1
2
Y.-s. Kim , S.-Y. Choi , Y.-J. Seo , J. Yang , M.J. Park , H.K. Lim , K.-S. Choi
(1) Samsung Medical Center, Sungkyunkwan University School of Medicine, Dept. Radiology,
Seoul, South Korea, (2) Molecular and Cellular Imaging Center, Samsung Biomedical Research
Institute, Seoul, South Korea
Page 19 of 28
A-364
1
Gas-filled Phospholipid Nanobubbles Conjugated with Gadolinium Play a Role as a
Potential Theragnostics for MR-guided HIFU Ablation
1
A-282
A-195
ISTU business and awards plenary
16:15
Remarks by the President
Larry Crum
Report by the Treasurer
Cyril Lafon
Report by the Secretary-General
Joo Ha Hwang
A new official journal of the ISTU and FUSF - The Journal of Therapeutic Ultrasound
Robert Muratore
Announcement Student Awards
Tom Leslie
Announcement of the Lizzi Award
Jean-Francois Aubry
Lizzi Award Lecture
Announcement of the Fry Award
Kullervo Hynynen
Fry Award Lecture
MR-guided focused ultrasound - Technology
Chairs:
8:30
Robotic active positioning technique for magnetic resonance-guided high-intensity
focused ultrasound
1
1
2
A-375
3
X. Xiao , Z. Huang , A. Volvick , A. Melzer
(1) University of Dundee, Dundee, United Kingdom, (2) Insightec, Israel, (3) Institute for
Medical Science and Technology, Dundee, United Kingdom
8:40
Adaptive Model-Predictive Controller Applied In Vivo
1
2
2
A-215
3
J. de Bever , N. Todd , A. Payne , R. Roemer
(1) University of Utah, School of Computing, Salt Lake City, United States, (2) University of
Utah, Utah Center for Advanced Imaging Research, Salt Lake City, United States, (3) University
of Utah, Mechanical Engineering, Salt Lake City, United States
8:50
Intracranial Treatment Envelope Mapping of Transcranial Focused Ultrasound
1
1
2
A-217
1
M. Eames , A. Hananel , N. Kassell , J. Snell
(1) Focused Ultrasound Surgery Foundation, Brain Program, Charlottesville, United States, (2)
University of Virginia, Neurosurgery, Charlottesville, United States
9:00
Validation Method for Shear Wave Tracking Using MR-ARFI
1
1
R. Bitton , K. Butts Pauly
(1) Stanford University, Department of Radiology, Stanford, United States
Page 20 of 28
A-225
9:10
A-236
Real-Time Method for Treatment of Mobile Organs and MR Thermometry by
MRgHIFU
1
2
1
1
2
3
2
Z. Celicanin , V. Auboiroux , O. Bieri , F. Santini , M. Viallon , K. Scheffler , R. Salomir
(1) University of Basel Hospital, Radiological Physics, Basel, Switzerland, (2) University Hospital
of Geneva, Radiology Department, Geneva, Switzerland, (3) MPI for Biological Cybernetics,
MRC Department, Tübingen, Germany
9:20
Mechanical effects of focused ultrasound observed in the R2* measurement
1
1
1
1
1
N. Todd , J. de Bever , H. Odeen , M. Diakite , A. Payne , D. Parker
(1) University of Utah, Salt Lake City, United States
9:30
1
MatMRI and MatHIFU: MatlabTM toolboxes for real-time monitoring and control of
MR-HIFU
1
2
3
A-284
A-117
1
T. Sinclair , C. Mougenot , J. Kivinen , S. Pichardo
(1) Thunder Bay Regional Research Institute, Image-guided Interventions, Thunder Bay,
Canada, (2) Philips Healthcare, Canada, (3) Lakehead University, Canada
9:40
Large volume, conformal mild hyperthermia with magnetic resonance-guided high
intensity focused ultrasound: implementation and application in drug dose painting
with image-able, temperature-sensitive liposomes
1
2
3
1
A-379
1
P.S. Yarmolenko , E.N. Carvajal Gallardo , A. Partanen , A. Ranjan , D. Woods , A.H.
1
1
2
1
1
Negussie , C. Burke , L. Bartels , B.J. Wood , M.R. Dreher
(1) National Institutes of Health, Center for Interventional Oncology, Radiology & Imaging
Sciences, Clinical Center, Bethesda, Maryland, United States, (2) Image Sciences Institute,
University Medical Center Utrecht, Utrecht, Netherlands, (3) Philips Healthcare, Cleveland,
Ohio, United States
Modeling therapeutic ultrasound
Chairs:
10:30
High performance computational framework for full wave FUS/HIFU modeling in
anatomical models
1
2
A-129
1
A. Kyriakou , E. Neufeld , N. Kuster
(1) IT'IS Foundation/ETH Zurich, Zurich, Switzerland, (2) IT'IS Foundation, Zurich, Switzerland
10:40
Development of Second-Order Nonlinear Wave Propagation Algorithms in Soft
Tissue
1
1
2
G. Vilenskiy , N. Saffari , G. ter Haar
(1) University College London, Mechanical Engineering, London, United Kingdom, (2) Institute
of Cancer Research, Physics Department, Sutton, United Kingdom
Page 21 of 28
A-272
10:50
Phase aberration correction for transcranial MRgFUS using a hybrid simulation and
MR-ARFI method
1
1
A-223
1
U. Vyas , E. Kaye , K. Butts Pauly
(1) Stanford University, Radiology, Palo Alto, United States
11:00
A-376
A rapid 3D model of abdominal organs for transcostal HIFU therapy
1
1
2
3
1
R. Cao , J. Gao , G. Corner , G. Nabi , Z. Huang
(1) University of Dundee, School of Engineering, Physics and Mathematics, Dundee, United
Kingdom, (2) Ninewells hospital and Medical School, Medical physics, Dundee, United
Kingdom, (3) Ninewells hospital, Department of urology, Dundee, United Kingdom
11:10
A-211
Combined modeling and measurement methods to calibrate nonlinear acoustic
fields of HIFU transducers
1
2
1
1
1
1
V. Khokhlova , P. Yuldashev , W. Kreider , M. Bailey , O. Sapozhnikov , L. Crum
(1) Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of
Washington, Seattle, United States, (2) Physics Faculty, Moscow State University, Moscow,
Russian Federation
11:20
A-226
Effects of acoustic nonlinearity and blood flow cooling during HIFU treatment
1
1
2
M. Solovchuk , T. Sheu , M. Thiriet
(1) National Taiwan University, Engineering Science and Ocean Engineering, Taipei, Taiwan,
(2) University of Paris # 6, Laboratoire Jacques-Louis Lions, Paris, France
11:30
1
1
1
1
1
J. Georgii , C. von Dresky , C. Schumann , S. Meier , D. Demedts , T. Preusser
(1) Fraunhofer MEVIS, Bremen, Germany
11:40
A-232
Efficient Numerical Simulation of High Intensity Focused Ultrasound Therapy
respecting Reflections and Deformations
1
A-273
Design of an ultrasound-guided transesophageal HIFU probe for treating atrial
fibrillation
1
1
1
2
1
1
E. CONSTANCIEL , W.A. N'DJIN , F. CHAVRIER , P. CHEVALIER , J.-Y. CHAPELON , C. LAFON
(1) Inserm, U1032, LabTau, Lyon, F-69003, France ; Université de Lyon, Lyon, F-69003, France,
LYON, France, (2) Unité de Rythmologie U50, Hospices Civils de Lyon, Hôpital Cardiovasculaire
Louis Pradel, 59 bd Pinel, 69677 Lyon-Bron Cedex, France, LYON, France
11:50
Calculation of power and radiation force using the Rayleigh integral
1
1
1
E. Martin , P. Gelat , A. Shaw
(1) National Physical Laboratory, Teddington, Middlesex, United Kingdom
Page 22 of 28
A-268
Standards and safety for HIFU applications
Chairs:
13:00
G. ter Haar
Institute of Cancer Research, Sutton, United Kingdom
13:20
Calibration of a Philips MR-Guided HIFU source by acoustic holography and
nonlinear modeling
1
2
2
1
3
A-137
1
W. Kreider , P. Yuldashev , O. Sapozhnikov , N. Farr , A. Partanen , P. Kaczkowski , M.
1
2
Bailey , V. Khokhlova
(1) University of Washington, Applied Physics Laboratory, Seattle, WA, United States, (2)
Moscow State University, Department of Acoustics, Physics Faculty, Moscow, Russian
Federation, (3) Philips Healthcare, Cleveland, OH, United States
13:30
Characterization of a New Fiber-Optic Hydrophone for High Intensity Acoustic
Fields
1
1
A-393
1
S.M. Howard , X. Chen , C.I. Zanelli
(1) Onda Corporation, Sunnyvale, CA, United States
13:40
High Intensity Therapeutic Ultrasound - Measurement and safety standards
1
2
3
4
A-264
5
R. Hekkenberg , T. Szabo , A. Shaw , S. Howard , M. Sekens
(1) Geast of TNO, Oude Wetering, NL, Netherlands, (2) University of Boston, Boston, US,
United States, (3) National Physical Laboratory, Teddington, UK, United Kingdom, (4) Onda
Corp, Sunnyvale, US, United States, (5) Siemens Healthcare, Seattle, US, United States
13:50
QA and Calibration Developments for HIFU
1
1
1
2
J. Civale , I. Rivens , G. ter Haar , A. Shaw
(1) Institute of Cancer Research, Sutton, United Kingdom, (2) National Physical Laboratories,
Teddington, United Kingdom
Page 23 of 28
A-201
12th International Symposium for
Therapeutic Ultrasound
Wednesday - June 13, 2012
Tumor Therapy
Chairs:
8:00
The Future of Cancer Treatment with Therapeutic Ultrasound
P. Huber
German Cancer Research Center, Heidelberg, Germany
8:20
Clinical phase I/II research on ultrasound thermo-chemotherapy in oral and
maxillofacial-head & neck carcinoma
1
2
2
A-378
1
G. Shen , G. Ren , W. Guo , Y. Chen
(1) Shanghai Jiao Tong University, Biomedical Instrument Institute, School of Biomedical
Engineering; Med-X Institute, Shanghai, China, (2) Shanghai Jiao Tong University, Department
of Oral and Maxillofacial Surgery, School of Stomatology, Ninth People's Hospital, School of
Medicine; Shanghai Research Institute of Stomatology, Shanghai, China
8:30
Robotic transrectal high intensity focused ultrasound at 3 MHz in localized prostate
cancer: Efficacy in 704 patients after 10 years
1
A-305
1
S. Thüroff , C. Chaussy
(1) Harlachinger Krebshilfe e.V, HIFU Projekt, München, Germany
8:40
Antitumor Effects of Combining Docetaxel and Paclitaxel with the Antivascular
Effects of Ultrasound Stimulated Microbubbles
1
1
2
1
A-363
1
M. Todorova , V. Agache , R. Karshafian , K. Hynynen , D. Goertz
(1) Sunnybrook Research Institute, Physical Sciences, Toronto, Canada, (2) Ryerson University,
Canada
8:50
Histotripsy Ablation of ACE-1 Implanted Prostate Tumor in a Canine Model
1
1
2
1
1
G. Schade , J. Keller , T. Rosol , E. Keller , W. Roberts
(1) University of Michigan, Urology, Ann Arbor, MI, United States, (2) The Ohio State
University, Veterinary Biosciences, Columbus, OH, United States
Page 24 of 28
A-98
9:00
Blood-Brain Barrier Disruption with Focused Ultrasound Allows Brain Tumour
Therapy with Targeted Immune Cells
1
2
2
3
A-392
1
R. Alkins , A. Burgess , M. Ganguly , W. Wels , K. Hynynen
(1) University of Toronto, Medical Biophyiscs, Toronto, Canada, (2) Sunnybrook Research
Institute, Imaging Research, Toronto, Canada, (3) Georg-Speyer-Haus, Chemotherapeutisches
Forschungsinstitut, Frankfurt, Germany
9:10
Irinotecan delivery by microbubble-assisted ultrasound - A pilot preclinical study
1
1
1
A-118
1
J.-M. Escoffre , A. Novell , S. Serrière , A. Bouakaz
(1) Inserm U930 - Imagerie & Cerveau, Université François Rabelais, Tours, France
9:20
A-348
Focused ultrasound therapy for vulvar intraepithelial neoplasia in mice
1
2
3
1
C. Li , L. CHEN , Y. JIA , C. LIN
(1) Biomedical Engineering College, Chongqing Medical University, Chongqing, People's R
China, Chongqing, China, (2) The Third People's Hospital of Chengdu City, Chengdu, Peoples R
China, Chengdu, China, (3) the First Affiliated Hospital, Chongqing Medical University,
Chongqing,, China
9:30
Short-Term Outcome of High-Intensity Focused Ultrasound Therapy for primary and
secondary liver cancer
1
2
2
2
3
4
A-199
4
H.H. Choi , J.H. Kim , H.M. Bae , C.S. Han , S.W. Gi , S.H. Son , I.B. Choi
(1) Comprehensive Hospital for Advanced Cancer, Surgery, Incheon, South Korea, (2)
Comprehensive Hospital for Advanced Cancer, Internal Medicine, Incheon, South Korea, (3)
Comprehensive Hospital for Advanced Cancer, Neuropsychiatry, Incheon, South Korea, (4)
Comprehensive Hospital for Advanced Cancer, Radiation Oncology, Incheon, South Korea
Drug delivery II
Chairs:
9:40
The Development of Cavitation-Enhanced Drug Delivery Utilizing A Conventional
Diagnostic Ultrasound Imaging System and Sonosensitive Nanoparticles
1
1
A-148
1
C. Coviello , P. Probert Smith , C.-C. Coussios
(1) IBME, University of Oxford, Dept of Engineering Science, Oxford, United Kingdom
9:50
A Novel Cardiac Extracorporeal Shockwave System for Enhancing the Efficacy of Cell
Therapy
1
2
1
2
2
2
2
W. Khaled , B. Assmus , A. Lutz , D. Walter , D. Leistner , S. Dimmeler , A. Zeiher
(1) Dornier MedTech, Research and Development, Wessling, Germany, (2) JW Goethe
University Frankfurt, Cardiology, Frankfurt, Germany
Page 25 of 28
A-170
10:00
1
1
1
1
1
M. Fabiilli , P. Sherman , C. Quesada , X. Shao , M. Piert , O. Kripfgans
(1) University of Michigan, Radiology, Ann Arbor, United States
10:10
A-218
Dynamic PET imaging of drug delivery and hypoxia using acoustic droplet
vaporization
1
Spatio-temporal mapping of drug release from thermally sensitive liposomes using
cavitation-enhanced ultrasonic heating.
1
1
A-341
1
E. Mylonopoulou , J.J. Choi , C.C. Coussios
(1) Institute of Biomedical Engineering, University of Oxford, Engineering, Oxford, United
Kingdom
10:20
Improved luciferase gene expression using ultrasound targeted microbubble
destruction therapy in swines
1
1
1
1
1
1
A-270
2
M.L. Noble , S. Song , R.R. Sun , L. Fan , R.M. DiBlasi , C. O Kelly-Priddy , K.R. Loeb , C.H.
1
Miao
(1) Seattle Children's Research Institute, Seattle, United States, (2) Fred Hutchinson Cancer
Research Center, Seattle, United States
10:30
Noninvasive and targeted gene delivery into the brain using microbubble-facilitated A-330
focused ultrasound
1
2
3
3
1
P.H. HSU , C.J. WEN , C.Y. WU , C.R. SHEN , H.L. LIU
(1) Chang Gung University, Department of Electrical Engineering, Tao-Yuan, Taiwan, (2) Chang
Gung Memorial Hospital, Animal Molecular Imaging Center, Tao-Yuan, Taiwan, (3) Chang
Gung University, Department of Medical Biotechnology and Laboratory Science, Tao-Yuan,
Taiwan
Page 26 of 28
Clinical studies of therapeutic ultrasound
Chairs:
11:00
A Phase 1 Study of Magnetic Resonance Guided Focused Ultrasound Thalamotomy
for the Treatment of Medication-Refractory Essential Tremor
1
1
1
1
2
A-398
3
J. Elias , S. Monteith , N. Kassell , M. Khaled , D. Huss , M. Wintermark
(1) University of Virginia, Neurosurgery, Charlottesville, United States, (2) University of
Virginia, Physical Therapy, Charlottesville, United States, (3) University of Virginia,
Neuroradiology, Charlottesville, United States
11:20
A-137
MR guided Focused Ultrasound Surgery for Small Breast Cancer: Its efficacy in
follow-up physical and images finding
1
2
1
1
1
2
1
H. Furusawa , J. Shidooka , M. Inomata , E. Hirabara , Y. Yasuda , H. Nakahara , Y. Maeda ,
1
K. Komaki
(1) Breastopia Namba Hospital, Beast Surgical Oncology, Miyazaki, Japan, (2) Breastopia
Namba Hospital, Diagnostic Radiology, Miyazaki, Japan
11:30
A-393
MR-HIFU ablation of human breast tissue leads to local tissue deformation
1
2
1
3
4
R. Deckers , L.G. Merckel , P. Baron , B. Denis de Senneville , R. Bleys , M.A.A.J. van den
2
1
Bosch , L.W. Bartels
(1) University Medical Center Utrecht, Image Sciences Institute, Utrecht, Netherlands, (2)
University Medical Center Utrecht, Radiology, Utrecht, Netherlands, (3) UMR 5251
CNRS/Université Bordeaux 1/INRIA, IMB, Bordeaux, France, (4) University Medical Center
Utrecht, Anatomy, Utrecht, Netherlands
11:40
A-209
MR Thermometry in Palliative Treatment of Bone Metastases by Focused
Ultrasound
1
1
1
Y. Huang , G. Czarnota , K. Hynynen
(1) Sunnybrook Research Institute, Toronto, Canada
11:50
Clinical evaluation of a toroidal High Intensity Focused Ultrasound transducer used
intra-operatively for the treatment of liver metastases
1
1
2
2
2
1
A-147
2
D. Melodelima , J. Vincenot , Y. Chen , A. Dupre , A. Gandini , J.-Y. Chapelon , M. Rivoire
(1) INSERM, LabTAU - U1032, LYON, France, (2) Centre Leon Berard, Department of Surgery,
LYON, France
12:00
Transrectal HIFU for the treatment of localized prostate cancer: 12-year experience
1
1
1
A-103
1
T. Uchida , H. Kim , S. Shoji , Y. Nagata
(1) Tokai University Hachioji Hopsital, Urology, Hachioji, Tokyo, Japan
12:10
Locally recurrent prostate cancer after initial radiation therapy: results of a
multicenter European study (418 patients)
1
2
A. Gelet , J.Y. Chapelon
(1) Hospices Civils de Lyon, Urology and transplantation surgery, lyon, France, (2) INSERM unit
1032, laboratory of therapeutic applications of ultrasound, LYON, France
Page 27 of 28
A-192
12:20
Efficacy of Focused Ultrasound in the Treatment of Vulvar Intraepithelial Neoplasia
1
2
A-345
1
C. Li , Y. JIA , C. LIN
(1) Biomedical Engineering College, Chongqing Medical University, Chongqing, People's R
China, Chongqing, China, (2) the First Affiliated Hospital, Chongqing Medical University,
Chongqing, China
Bioeffects of therapeutic ultrasound
Chairs:
8:00
A-241
Reporting Ultrasound Exposure Conditions for Bio-Effects Studies
1
2
A. Shaw , G. ter Haar
(1) National Physical Laboratory, Teddington, United Kingdom, (2) Institute for Cancer
Research, Sutton, United Kingdom
8:10
A-259
Intravital Microscopy with FITC-dextran to Detect Effects of Shock Waves on
Microcirculation
1
2
3
3
2
W. Khaled , O. Goertz , J. Hauser , H. Lauer , M. Lehnhardt
(1) Dornier MedTech, Research and Development, Wessling, Germany, (2) BGU-Ludwigshafen,
University hospital for plastic surgery and burn injury, Ludwigshafen, Germany, (3) RuhrUniversity Bochum; BG-Bergmannsheil, University hospital for plastic surgery and burn injury,
Bochum, Germany
8:20
A-309
Histological and functional studies of isolated arteries containing contrast agents
exposed to high intensity focused ultrasound
1
1
1
A. Tokarczyk , I. Rivens , G. ter Haar
(1) Institute of Cancer Research, Physics, Sutton, United Kingdom
8:30
A-196
High Intensity Focused Ultrasound (HIFU) on dental biofilm
1
2
3
2
4
S.-W. Ohl , K. Iqbal , A.S. Fawzy , J.C.L. Neo , B.C. Khoo
(1) Institute of High Performance Computing, Singapore, Singapore, (2) National University of
Singapore, Restorative Dentistry Department, Singapore, (3) National University of Singapore,
Oral Sciences, Faculty of Dentistry, Singapore, (4) National University of Singapore, Mechanical
Engineering, Singapore
8:40
A-298
Comparison of Ultrasonic Atomization of Tissue and Liquids
1
1
1
1
1
O. Sapozhnikov , J. Simon , V. Khokhlova , T. Khokhlova , W. Kreider , M. Bailey
(1) University of Washington, Applied Physics Laboratory, Seattle, United States
8:50
1
A-171
Biological effects induced by therapeutic ultrasounds on cell line
1
1
1
2
3
3
C. Giliberti , A. Bedini , R. Palomba , I. Udroiu , D. Pozzi , S. Morrone , A. Congiu Castellano
(1) INAIL, Italy, (2) University Sapienza, Italy, (3) Università Sapienza, Italy
Page 28 of 28
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