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Studies with reports of febrile neutropenia with docetaxel use
Population
n
Cancer type
Treatment
Docetaxel dose
(mg/m2/3weeks)
100-105
FN rate
European
4950
breast
European
1010
breast
Chinese
Caucasian
Asian
47
43
23
NSCLC
NSCLC
Doxorubicin + cyclophosphadmide
then paclitaxel or docetaxel
Docetaxel + FEC or vinorelbine +
FEC, +/- trastuzumab
Docetaxel alone
Docetaxel + carboplatin
16%
(1)
100
23% (no trastuzumab),
29.6% (with trastuzumab)
41.70%
18.60%
39.10%
(2)
Chinese
102
NSCLC
Docetaxel vs. pemetrexed
75
Mixed (86%
Caucasian)
Greek
Mixed (85%
Caucasian)
Chinese
Chinese
72
NSCLC
Docetaxel + carboplatin
75
27.6%
(grade 3-4 neutropenia)
8.30%
43
506
NSCLC
breast
Docetaxel + gemcitabine
Docetaxel + cyclophosphamide
100
75
14.00%
5.00%
59
28
Docetaxel alone
Gemcitabine + docetaxel
100
75
14%
4%
Docetaxel + cisplatin + 5FU
60
13%
Docetaxel + carboplatin
Docetaxel + capecitabine/
epirubicin
Docetaxel + oxaliplatin +
capecitabine
Docetaxel + cyclophosphamide
105
75
2%
2-11%
(11)
(12)
(13)
75
30%
(14)
75
with G-CSF
no G-CSF
grade 3 FN
retrospective analysis
(15)
75
75
Remarks
Ref
(3)
(4)
carboplatin dose had
to be reduced after
first 6 S'pore patients
(5)
(6)
G-CSF given
(7)
(8)
Chinese
32
Chinese
Chinese
43
92
breast
soft tissue
sarcoma
gastric or
GEJ
NSCLC
breast
Chinese
30
gastric
Asian
(mixed, S'pore)
Chinese
Indian
(Mumbai)
Indian
(New Delhi)
Indian
(Mumbai)
Indian
(Mumbai)
159
breast
48
31
gastric
esophageal
& GEJ
breast
Docetaxel + oxaliplatin
Docetaxel + cisplatin + 5FU
60
75
6%
25%
7%
39%
DEC or FEC + docetaxel
75 or 85
15%
retrospective analysis
(18)
Hypopharyngeal
oral cavity
Cisplatin + docetaxel +/- 5FU
75
4%
retrospective analysis
(19)
Cisplatin + docetaxel +/- 5FU
75
3.1% (2 drugs),
34.6% (3 drugs)
retrospective analysis
(20)
96
59
123
(9)
(10)
(16)
(17)
Indian (Jaipur)
44
Chinese
Malays
Indians
32
14
4
Head &
neck
breast
Cisplatin + docetaxel +/- 5FU x 23cycles then weekly cisplatin + RT
docetaxel/doxorubicin vs.
docetaxel + ketoconazole
75
13.6% (during induction)
retrospective analysis
(21)
75
77%
57%
75%
data for conventional
arm only, these are
grade 4 neutropenia
rates, not FN
(22)
FN: febrile neutropenia, Ref: reference: FEC: fluorouracil + epirubicin + cyclophosphamide, S’pore: Singapore, NSCLC: non small
cell lung cancer, G-CSF: granulocyte-colony stimulating factor, DEC: docetaxel + epirubicin + cyclophosphamide, GEJ:
gastroesophageal junction, 5FU: fluorouracil, RT: radiotherapy
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1.
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2.
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3.
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11.
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12.
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13.
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