European Respiratory Society Annual Congress 2012

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European Respiratory Society
Annual Congress 2012
Abstract Number: 1554
Publication Number: P930
Abstract Group: 4.3. Pulmonary Circulation and Pulmonary Vascular Disease
Keyword 1: Elderly Keyword 2: Longitudinal study Keyword 3: Pulmonary hypertension
Title: Factors determining outcome in patients with heart failure and normal ejection fraction
Ms. Caroline 6409 Tufaro [email protected] 1, Prof. Dr Julia 6410 Mascherbauer
[email protected] MD 1, Dr. Beatrice 6411 Marzluf [email protected]
MD 1, Prof. Dr Thomas 6412 Binder [email protected] MD 1, Prof. Dr Irene 6413 Lang
[email protected] MD 1 and Prof. Dr Diana 6414 Bonderman
[email protected] MD 1. 1 Department of Internal Medicine II, Division of Cardiology,
Medical University Vienna, Austria .
Body: Background: Patients with heart failure and normal left ventricular ejection fraction (HFNEF) face an
adverse outcome. Our aim was to identify factors that determine prognosis. Methods: Patients diagnosed
according to current ESC guidelines were recruited. Death and/or hospitalization for HF were defined as
primary outcome variables. Outcome groups were compared with respect to potential prognostic predictors
using the t-test. Multivariable logistic regression analysis determined whether parameters of interest were
associated with adverse outcome. P<0.05 indicated statistical significance. Results: Between December
2010 and January 2012, 49 patients (34 f/ 15 m, mean age 70±8 years) were registered. After a mean
follow-up of 5±9 months, 14 (29%) patients were hospitalized or died. The adverse outcome group was
characterized by higher body mass index (BMI, 35±7 versus 29±5, p=0.004), higher systolic pulmonary
pressure on echo (sPAP in mmHg, 69±15 versus 55±14, p=0.004), shorter 6-minute walk distance (6-MWD
in m, 271±131 versus 364±100, p=0.019), higher transpulmonary gradient (TPG in mmHg, 15±4 versus
12±4, p=0.013) and a higher pulmonary vascular resistance (PVR in dynes.s/cm5, 257±97 versus 198±71,
p=0.030). Diabetes mellitus II (DM II, 75% versus 24%, p=0.002) and atrial fibrillation (92% versus 51%,
p=0.013) were more prevalent among patients with adverse outcome. In the multivariable regression model,
only DM II (OR 25.34[95% CI, 2.06 to 311.45]; p=0.012), BMI (OR 1.25[95% CI, 1.00 to 1.56]; p=0.048), and
PVR (OR 1.02[95% CI, 1.00 to 1.05]; p=0.032) remained independent predictors of outcome. Conclusions:
Presence of DM II, higher BMI and higher PVR worsen prognosis in HFNEF patients.

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