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Society of Toxicology
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Society of Toxicology
About SOT
Special Issue 2004
Manage Membership
News in This Issue
Join SOT
People & Groups
Services & Resources
Events & Meetings
Visit the 2015 Annual
Meeting Website
Mark You Calendar
for SOT 2016:
March 13–17
New Orleans, Louisiana
President's Message
Bringing the Society of Toxicology (SOT) to mind when questions are asked and when decisions are
made about chemical and biological hazards, exposures to these substances, and risk (or lack thereof)
is important for the enhancement of our discipline. To aid in meeting this need in this time of electronic
communication, SOT has much information, including links to toxicology-related sites on its Web site.
The SOT Web site is maintained by SOT Headquarters, working on the advice of the World Wide Web
Advisory Committee (Jim Kehrer, Chair, Michael Dourson, Robert J. Kavlock, Brian Mathison,
Allan Parrish, Ruth Roberts, members, Sachin Bendre, student representative, Bill Greenlee,
liaison to SOT Council, and Deborah O’Keefe, Headquarter’s Liaison).
There are times when information asked of toxicologists is in response to a very specific need, which is
true in times of local, regional, national or international emergency. It is for this reason that past
president Dave Eaton commissioned the Task Force on Chemical/Biological Terrorism Resource
Registry, co-chaired by Ron Riley and Steve Channel, with members Nancy Adams, Steve Baskin,
Alan Katz, Moiz Mumtaz, George Rusch, Harry Salem and Cody Wilson. This task force has
contributed to the SOT Web site by providing information on Bioterrorism/Chemicals Resources and
Bioterrorism Links.
In addition, the Task Force is working to position SOT and its members to be the source for specific
expert advice that could be utilized upon request from government agencies and other valid
organizations in need of this expertise for strategic planning or tactical response. Although the
immediate purpose is to provide expertise of value in times of chemical and/or biological terrorist
activities, the longer-term goal is to provide a registry of experts to assist in planning responses to a
variety of emergencies. To do this, the Task Force is working on creating a registry of SOT members
that could provide information on agents, their properties and toxicities, and instruction or assistance
in developing risk assessment approaches. This registry will be most successful if it is reasonably large,
including several hundred toxicologists with a wide variety of expertise. The expertise of the many
toxicologists then is to be sorted so it is relatively specific to meet the needs of the requesting agency.
For this reason, the Task Force has developed a detailed questionnaire for identifying SOT members
with specific expertise. The Task Force encourages all SOT members, even those who think their areas
of expertise are peripheral to chemical and biological terrorism, to participate, as expertise in hazard
evaluation, exposure evaluation, and risk assessment are especially valuable. This is because the
purpose of this registry goes beyond terrorism—it is designed to provide general expertise for
emergency preparedness. The larger the number of toxicologists included in the registry, the more
valuable and more long-lasting it becomes. Participants can be assured that the information they
provide for this registry is confidential and that it will not be shared without their permission. I would
strongly encourage all of you to respond to the request of the Task Force and complete the
questionnaire for the registry.
Marion F. Ehrich, Ph.D.
2003–2004 SOT President
The NIH Roadmap: A Strategic Plan for Medical Research
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A strategic plan for medical research at National Institutes of Health (NIH) has been developed in the
months since Elias A. Zerhouni, assumed position as NIH Director in May 2002. The purpose was to
identify major opportunities and gaps in biomedical research. According to NIH, their goal is to support
“an integrated vision to deepen understanding of biology, stimulate interdisciplinary research teams,
and reshape clinical research to accelerate medical discovery and improve people’s health.” The NIH
Roadmap accelerating medical discovery to improve health can be viewed on the NIH Web Site.
It identifies the three most compelling opportunities NIH sees in health research—new pathways to
discovery, research teams of the future, including interdisciplinary research and public-private
partnerships, and enhancement of clinical research. Research initiatives are already forthcoming,
including those intended to encourage cutting-edge, risk-taking research to hasten improvements in
human health, and initiatives intended to support interdisciplinary research centers.
2004–2005 Councilors and Committee Members Selected
The results of the Society of Toxicology 2004–2005 election are as follows:
Vice President-elect:
James Popp
Norbert E. Kaminski
Yvonne Dragan and
Elaine M. Faustman
Awards Committee:
Kim Boekelheide,
Deborah A. Cory-Slechta, and Annie Jarabek
Education Committee:
Michelle J. Hooth and
B. Paige Lawrence
Membership Committee:
Jeanine L. Bussiere and
Jack R. Harkema
Nominating Committee:
Peter L. Goering
(from Regional Chapters)
Matthew Bogdanffy
(from Specialty Sections)
Dan Acosta, Jr.
(from Past Presidents)
Myrtle A. Davis
SOT congratulates the new Councilors and elected
committee members!
Contribute Your Knowledge
Below are two new opportunities for scientists to share their excitement about, and expertise in,
toxicology with students. Research has shown that direct interaction with a scientist role model can
significantly increase student performance in school, increase interest in learning and, most
importantly, build self-confidence in their own abilities. You can make a difference!
NEC Give a Day, Make a Difference. Scientists and engineers across the U.S. are spending part of a
day in middle schools to tell students about the wonders of science, mathematics, and technology and
the opportunities for rewarding future careers. Toxicologists are invited to join this important effort.
The event, led by Science Service and NEC Foundation of America, continues through April. The
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foundation makes it easy by helping participants contact local schools, suggests classroom activities,
and can even provide press kits. For more information and to sign up, visit the Science Service Web
Assist as an AskNSDL Expert. Will you help answer questions about science? The Excellence in
Science, Technology, and Mathematics Education (ESTME) Week is March 15-20 and members of the
scientific community are conducting many activities to encourage bright minds to pursue careers in
these fields. ESTME Week is co-sponsored by the National Science Foundation and the Department of
Education. During this week, through the ESTME Web Site, and March 16 during the Equations ‘04
Exposition in Washington, D.C., the National Science Digital Library (NSDL) will provide responders for
those who want to “Ask a Scientist or Engineer” as part of the NSDL virtual reference desk. Experts can
sign up to answer questions in any of the specified areas, several of which are related to toxicology. To
register, go to the Web site and select the “experts” tab and follow the instructions. To facilitate your
registration, please include in the “credentials/bio” field that you are a member of SOT, a partner in
the NSDL Biology Educators Network project.
Congratulations to the 2004 SOT Award Winners
Achievement Award
David Dorman
Arnold J. Lehman Award
Melvin E. Andersen
Board of Publications (BOP) Best Paper Award
Inhaled Environmental Combustion Particles Cause Myrocardial Injury in the Wistar Kyoto Rat, Urmila
Kodavanti, Carolyn Moyer, Allen Ledbetter, Mette Schladweiler, Daniel Costa, Russ Hauser,
David Christiani and Abraham Nyska, Toxicological Sciences 71, 237-245 (2003).
Contributions to Public Awareness of the Importance of Animals in Toxicology Research
Distinguished Lifetime Toxicology Award
Gerald N. Wogan
Education Award
A. Jay Gandolfi
Merit Award
Robert Goyer
Public Communications Award
Kenneth Olden
SOT/American Chemistry Counci/Early Career Award in Neurotoxicology
Nikolay Filipov
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AstraZeneca Traveling Lectureship Award
Charlene A. McQueen
Colgate-Palmolive Traveling Lectureship in Alternative Methods in Toxicology Award
Snorri S. Thorgeirsson
SOT/IUTOX AstraZeneca Travel Award
Xianping Ying, P. K. Gupta, Salmaan Inayat-Hussain, and Christina Bolaton
New Communiqué “Just Right” in Survey
The decision to move to a mostly electronic Communiqué followed a calculated assumption
that this is what you and other readers wanted. Our plan included asking you if this is right,
once you received several Communiqués in the new format. After about a year since
crossing this electronic divide, you and other SOT members responded very positively to a
November survey asking if our new electronic format met your needs.
Over 90% read 4 or all 5 newsletters each year, and 80% do more than casually browse.
Your favorite reading includes Annual Meeting Information (80%), Position Papers (57%),
and Social Activities / News (56%), while you read less often about Regional Chapter News
(25%) and Job Opportunities (33%). This must mean that most are happy with their current
employers. A large majority describe the Communiqué as useful, interesting, informative,
and a strong connection to SOT (75-80%). When asked what the ideal Communiqué would
be like, you prefer to receive 4 (39%) or 6 (29%) issues of the current length (71%), with
an increased proportion of administrative and news content (57%) or with the current
balance of 80% administrative and 20% science content (38%). Finally, 53% like delivery
as is, while 34% would be happy if all issues were electronic and delivered by e-mail. Many
of you gave specific suggestions on where and what to adjust, and these comments will help
us make the content of future issues serve all of you to the best of our ability.
If you did not respond to the newsletter survey, but would like to make recommendations,
e-mail your comments to George Corcoran or incoming Communiqué Editor Gary Carlson at
[email protected], or [email protected], respectively. We really do want your help in
making the Communiqué as good as it can possibly be.
Thanks to all who read the Communiqué, and particularly to those who responded to the
Publications for Students from the SAC
The spring edition of the SOTudent e-Letter is now available.
This twice-a-year publication is one of the ways that the SOT’s Student Advisory Committee
(SAC) keeps the Student Membership informed of important announcements and activities.
The current edition is packed with information about student activities at the Society of
Toxicology 2004 Annual Meeting in Baltimore as well as updates on membership and
Regional Chapter activities. Download your copy today! The number of activities for students
has dramatically increased this year.
For special tips and specifics on student activities at the Annual Meeting you will also want
to access the SOT Annual Meeting Student Event Planner. If you choose to register when you
download the Planner, you will also be eligible for prizes during the Student Mixer March
21st. Don’t miss out!
See you at SOT 2004!
Annual Meeting News
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Annual Meeting Exhibitors
Company Name
AAALAC International
Abraxis, LLC.
ACS Publications
AEgis Technologies Group, Inc. (The)
Agilent Technologies
Alabama Research & Development
Allentown Caging Equipment Co., Inc
Alternative Design Manufacturing & Supply, Inc.
Althea Technologies
ALZET® Osmotic Pumps
American Association for Laboratory Animal Science (AALAS)
American Board of Toxicology (ABT)
American College of Toxicology (ACT)
Anew International
Ani Lytics, Inc.
Anilab, Inc.
Animal Identification and Marking Systems, Inc. (AIMS)
Animals In Research Booth (AIR)SOT
Applied Biosystems
Applied Pre-Clinical Services
AppTec Laboratory Services
Atsdr/Division of Toxicology
BAS Evansville
Battelle HHS
BBL Sciences
BD Biosciences
Bench International
Bio Medic Data Systems, Inc.
BioRad Laboratories, Informatics Division
BioServ, Inc.
Biological Test Center (BTC)
Biologix Research Company
Biomind, LLC
Biosense Laboratories AS
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BioSTAT Consultants, Inc.
Biotrin International
Brady Corporation
BristolMyers Squibb (BMS)
Bruker Daltonics, Inc.
Burdock Group
Buxco Research Systems
Calvert Laboratories, Inc.
Cayman Chemical
CeeTox, Inc.
CELLnTEC Advanced Cell Systems
Central Toxicology Laboratory Syngenta (CTL)
CH Technologies (USA) Inc.
ChanTest, Inc.
Charles River Laboratories
Charles River Laboratories Development Services (DDS)
Charles River Laboratories Discovery & Development Services
Charles River Laboratories Discovery Services
ChemSensing, Inc.
Chenomx, Inc.
CIIT Centers for Health Research
Ciphergen Biosystems, Inc.
Colorado HistoPrep
Comparative Biosciences Inc.
Comparative Ophthalmic Research Lab.
Cosmetic Ingredient Review (CIR)
Coulbourn, Inc.
Covance Research Products, Inc.
CTBR (A Member of the Inveresk Research Group)
DaiyuKai Inst. Med. Sci.
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Data Sciences International
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DaVinci Biomedical Research Products
Detroit R & D, Inc.
Dow Corning Corporation
Druquest International, Inc.
Eastern Medical Publishers
Elm Hill Breeding Labs, Inc.
Elsevier Science
Environ International
Environmental & Occupational Health Sciences Institute
Environmental Health Perspectives (EHP)
Enzo Life Sciences, Inc.
EPL, Inc. (Experimental Pathology Laboratories)
Expression Analysis
Fraunhofer ITEM
Gene Logic, Inc.
GeneXP Biosciences
Genospectra, Inc.
Gentronix Limited
Gould Instrument Systems, Inc.
Graham Laboratories
H&T Corporation
Hamilton Thorne Biosciences, Inc.
HamiltonKinder, LLC
Hatteras Instruments, Inc.
HemoGenix LLC
Hill Top Research, Inc.
Hilltop Lab Animals, Inc.
Human Biologics International (HBI)
Humana Press
Huntingdon Life Sciences
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IIT Research Institute
In Vitro Technologies, Inc. (IVT)
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Ina Research Inc.
Instech Solomon
Instem Life Science Systems
International Life Sciences Institute (ILSI)
Inveresk Research
IPS Therapeutique, Inc.
ISIS BioComp
Jackson ImmunoResearch Laboratories, Inc.
Jai Research Foundation (JRF)
K12 Resources Booth SOT
Kent Scientific Corporation
Korea Institute of Toxicology (KIT)
LAB Pre-Clinical Research International
LAB Products, Inc.
LabCorp Pre-Clinical
Leadscope, Inc.
LHASA Limited
Lippincott Williams & Wilkins
Loats Associates, Inc.
Lomir Biomedical, Inc.
Lovelace Respiratory Research Institute (LRRI)
Marshall Farms USA, Inc.
MB Research Labs, Inc.
MDL Information Systems, Inc.
MDS Pharma Services
Med Associates
Medical College of Wisconsin, Rat Genome Database
Membership Booth SOT
Merck Research Laboratories
Metabometrix, Ltd.
Modular Instruments, Inc.
Molecular Light Technology UK (A GenProbe Company) (MLT)
MPI Research
NALGENE Brand Products
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National Library of Medicine
National Toxicology Program (NTP)
Next Century Incorporated
NIEHS Community Outreach and Education Program
Northview Biosciences, Inc.
Notocord Systems
Nucro-Technics Incorporated
Oxford University Press
Paradigm Genetics/Tissue Informatics
Pathology Data Solutions, Inc.
Pathology Solutions, Inc.
Pfizer Global Research and Development (PGRD)
PharmQuest Corporation
Popper & Sons, Inc.
Pre-Clinical Research Associates (PRA)
Primate Products, Inc. (PPI)
Product Safety Labs
Promega Corporation
Provident Pre-Clinical, Inc.
Puracyp, Inc.
Purina Mills LabDiet
QBM Cell Science
Quest Pharmaceutical Services, L.L.C. (QPS)
Quintiles, Inc.
Rallis India Limited
RASS (Risk Assessment Summer School)
Razel Scientific Instruments, Inc.
RCC Ltd.
Research Animal Diagnostic Laboratory University of Missouri
Research Diets, Inc.
Ricerca Biosciences
Roche Applied Science
Roundtable of Toxicology Consultants
RTC, Research Toxicology Centre S.p.A.
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RTI International
Safepharm Laboratories, Ltd.
San Diego Instruments, Inc.
Saronyx, Inc.
Schleicher & Schuell BioScience, Inc.
SCIREQ, Inc. (Scientific Respiratory Equipment)
Sequani Limited
SFBC International
Sinclair Research Center, Inc.
Skeletech, Inc.
Smiths Medical MD, Inc.
Society of Quality Assurance (SQA)
Southern Research Institute
Spring Valley Laboratories, Inc.
Springborn Smithers Labs (SSL)
SRI International
StemCell Technologies, Inc.
Stillmeadow, Inc.
Talos MSDS Authoring and Distribution Software
Tandem Labs
TBJ, Incorporated
Tecniplast USA, Inc.
The Baker Company
The Jackson Laboratory
The Toxicology Group, LLC
Thoren Caging Systems, Inc.
Tissue Transformation Technologies
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Toxicology Education Foundation (TEF)
Toxicology Excellence for Risk Assessment (TERA)
Toxicology Regulatory Services, Inc. (TRS)
Toxicology Research Laboratory
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Toxikon Corporation
TSE Technical & Scientific Equipment GmbH
U.S. Environmental Protection Agency (EPA)
Viking Medical/Used
Vitrocell Systems
Vitron, Inc.
WIL Research Laboratories
Wildlife International, Ltd.
Write to Congress (RALA)SOT
Xenobiotic Detection Systems
XenoTech, LLC.
Xybion Medical Systems
Zen-Bio, Inc.
SOT 25-Year Members
Mohamed B Abou-Donia, PhD, ATS, DABT
Daniel Acosta, Jr, PhD, RPh
Edgar M Adams, PhD
Richard H Adamson, PhD
Helmer P K Agersborg, PhD
Yves Alarie, PhD, DABT
Anthony M Ambrose, PhD
Bruce N Ames, PhD
M W Anders, DVM, PhD
Melvin E Andersen, DPhil, CIH, DABT
Robert C Anderson, ScD, Hon
F D Andrew, PhD, DABT
Arthur L Aronson, DVM, PhD
Bernard D Astill, PhD
Steven D Aust, PhD
Anne P Autor, PhD
Domingo M Aviado, MD
John G Babish, PhD
Kenneth C Back, PhD
Robert E Bagdon, PhD, DABT
Walter J Bagdon, PhD, DABT
Bryan Ballantyne, DSc, MD, PhD
Oneil M Banks, PhD, CIH, DABT
Lloyd W Beck, PhD
Robert P Beliles, PhD, DABT
John U Bell, PhD, DABT
Karl Friedrich Benitz, MD
Donald R Bennett, MD, PhD
George G Berg, PhD
William O Berndt, PhD, ATS, DABT, Fellow
Herman A Birnbaum, BS
Dr Robert V Blanke
Marvin J Bleiberg, PhD, DABT
Herbert Blumenthal, PhD
Joseph F Borzelleca, PhD
James A Botta, Jr, DVM, PhD
Gale C Boxill, PhD
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Carl E Boyd, MD
Balbir S Brar, DVM, PhD
Monique C Braude, PhD
Thomas P Bright, MD
Jules Brodeur, MD, PhD, DABT
Theodore M Brody, PhD
Daniel J Brown, PhD
David Robert Brown, ScD
W Ray Brown, DVM, PhD, AVCP
Paul E Brubaker, PhD
James V Bruckner, PhD
David J Brusick, PhD
Harold H Bryant, PhD
John A Budny, PhD
Edwin V Buehler, PhD, DABT
Donald R Buhler, PhD
John J Burns, PhD
Evelyn G Burtis, BS
William M Busey, DVM, PhD
Harpal S Buttar, DVM, PhD
James L Byard, PhD, DABT
Haney B Camp, PhD
Gary P Carlson, Jr, PhD
Robert G Carlson, DVM, PhD
Vernon L Carter, Jr, DVM, DABT
Marvin T Case, PhD, DVM
Thomas R Castles, II, PhD, DABT
Jose Alberto Castro, PhD
Finis L Cavender, PhD, DABT
Saroj K Chakrabarti, PhD
George M Cherian, PhD
Charles F Chesney, DVM, PhD, RAC
Rajendra S Chhabra, PhD, DABT
Clinton O Chichester, III, PhD
Byong Han Chin, PhD
Herbert E Christensen, DSc
Mr Emil E Christofano, BS
Ho Chung, PhD
Robert Clark, PhD
Thomas W Clarkson, PhD
John J Clary, DPhil, ATS
J Wesley Clayton, Jr, PhD
Eric D Clegg, PhD
David Coffin, VMD
Steven D Cohen, DSc, ATS
Jerome F Cole, ScD
Thomas F X Collins, PhD
Naomi I Condra, BS
Allan H Conney, PhD
Herbert H Cornish, PhD, DABT
George J Cosmides, PhD
Val F Cotty, PhD, DABT
Claude B Coutinho, MD, PhD
Joan M Cranmer, PhD
Morris F Cranmer, PhD
Chester R Crawford, PhD, DABT
Rose Dagirmanjian, PhD
John W Daniel, PhD, DSc
Thomas D Darby, PhD
Kenneth I Darmer, Jr, MS
Bernard Davidow, PhD
Joseph R Davis, MD, PhD
Kent J Davis, DVM
Salvatore J De Salva, PhD
Felix A De la Iglesia, MD
Walter J Decker, PhD
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Robert H Denlinger, PhD, VMD, DACVP
Durisala Desaiah, PhD, FATS
Claire E Dick, PhD
Robert M Diener, MS, DVM, ATS, DACVP, Fe
Elmwood O Dillingham, PhD
Louis C Dipasquale
Ernest M Dixon, MD, ScD
John J Domanski, Jr, PhD, DABT
Abel M Dominguez, PhD
H Wyman Dorough, PhD
Frank N Dost, DVM
J Fielding Douglas, PhD
John Doull, MD, PhD
David T Drees, DVM, PhD, DABT
Robert T Drew, PhD, DABT
Kurt M Dubowski, PhD
Pierre A Dumont, PhD
William F Durham, PhD, DABT
Andrew G Ebert, PhD
Donald J Ecobichon, PhD
John R Elsea, PhD
James L Emerson, DVM, PhD
John L Emmerson, PhD
Hugh L Evans, PhD
Michael A Evans, PhD, DABT
Raymond J Fabian, PhD
Morris D Faiman, PhD
Theodore M Farber, PhD, DABT
Ernest S Feenstra, DVM, PhD
Dr John F Ferrell
Bryan S Finkle, PhD
James E Fitzgerald, DVM, PhD
Frederick W Fochtman, PhD, DABT
Ralph W Fogleman, DVM
Bruce A Fowler, PhD, ATS
Ralph I Freudenthal, PhD
Jack Freund, MD
Leonard Friedman, PhD
Marvin A Friedman, PhD, DABT
Seymour L Friess, PhD
Harald Frohberg, MD
James M Fujimoto, PhD
George C Fuller, PhD, DABT
Angelo R Furgiuele, PhD
Dr Arthur Furst
Thomas B Gaines, BS
Michael A Gallo, PhD, DABT
A Jay Gandolfi, PhD
Robert W Gardier, PhD
Donald E Gardner, PhD, Fellow ATS
Paul J Garvin, Jr, MS
Robert G Geil, DVM, DABT
David J George, PhD
James E Gibson, PhD, ATS
James Robert Gibson, PhD, DABT
Martin R Gilman, PhD
Ralph Gingell, PhD, DABT
William H Gingerich, PhD
Shri N Giri, DVM, PhD, DABT
Mr. Hyman R Gittes, BA
Michaela Giurgea, MD
Vera C Glocklin, PhD
Christian Gloxhuber, MD
Frans C Goble, ScD
Leo R Goldbaum, PhD
Alan M Goldberg, PhD
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Morton E Goldberg, DSc
Edwin I Goldenthal, PhD
Joyce A Goldstein, PhD, DABT
Gio Batta Gori, MPH, DSc, Fellow ATS
Robert E Gosselin, MD
Theodore E Gram, PhD
Donald L Grant, PhD
Jack E Gray, DVM
William D Gray, PhD
Sidney Green, PhD, ATS
John F Griffith, PhD
Mr Edward J Groskinsky, BS
Dr Stanley B Gross
Anthony M Guarino, PhD
F Peter Guengerich, PhD
Wallace L Guess, PhD
Albert F Gunnison, PhD
Ruben J Guzman, MS
John G Hadley, PhD
Carl L Hake, PhD, DABT
Larry L Hall, PhD, DABT
Richard L Hall, PhD
Duane W Hallesy, PhD, DABT
Joseph P Hanig, PhD, ATS, DABT, FATS, Fe
Raymond D Harbison, PhD
Kenneth H Harper, PhD
Elliott S Harris, PhD
Lewis E Harris, ScD
Steadman D Harrison, Jr, PhD, DABT
Mr Ralph E Hartnagel, Jr, BS
Rolf Hartung, PhD
John N Hathcock, PhD
Mr Charles C Haun, BS
A. Wallace Hayes, DPhil, ATS, DABT, FATS
Johnnie R Hayes, PhD, DABT
Robert M Hehir, PhD
Mary C Henry, PhD
Eugene H Herman, PhD
Robert Hess, MD
Irwin A Heyman, PhD
Ralph Heywood, DVM
Bernard E Hietbrink, PhD
John Higginson, MD
Benjamin Highman, MD
Richard A Hiles, PhD
Jack A Hinson, PhD
David E Hinton, PhD
Mark Hite, ScD, DABT
Ing Kang Ho, PhD
Ernest Hodgson, PhD
David J Holbrook, Jr, PhD
Richard L Hollingsworth, CIH, DABT
Robert M Hollingworth, PhD
G Carl Holsing, PhD, DABT
Joseph F Holson, PhD
Elton R Homan, PhD,
Jerry B Hook, PhD, DABT
Marjorie G Horning, PhD
Dennis P H Hsieh, ScD
Arthur Hume, PhD
Benjamin A Jackson, MBA, PhD
Rudolph J Jaeger, PhD, DABT
Naresh C Jain, PhD
Lynn F James, PhD
William E Jaques, MD
Frederick R Johannsen, PhD, DABT, Fellow
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David C L Jones, PhD
Sam Kacew, PhD
Tetsuya Kamataki, PhD
Edward J Kaminski, PhD, DABT
Leon A Kanegis, DVM, PhD
Harold L Kaplan, PhD
Sidney Kaye, PhD
William T Keane, MS, DSc
John G Keller, PhD
Bruce J Kelman, PhD, DABT
Gerald L Kennedy, Jr, , DABT
Moreno L Keplinger, PhD
Renate D Kimbrough, MD, DABT
Carole A Kimmel, PhD
Georg Kimmerle, MD
Eugene T Kimura, PhD
Victoria Kindt, MD, PhD
Theodore O King, MD, PhD, DABT
Mr Edwin R Kinkead, BS
Florence K Kinoshita, PhD, DABT
John C Kirschman, PhD
Henry M Kissman, PhD
Curtis D Klaassen, PhD, DABT
Claus Klotzsche, MD
James B Knaak, PhD
Richard J Kociba, DVM, PhD, DABT
James J Kocsis, PhD
Jiro K Kodama, PhD
Charles J Kokoski, PhD,
Loren D Koller, DVM, PhD, ATS
Francis J Koschier, PhD, DABT
Frank N Kotsonis, PhD, DABT
Walter J Krasavage, MS
Herman F Kraybill, PhD
Robert I Krieger, PhD, ATS
Stephen Krop, PhD
Joseph S Kulesza, BS
Arun P Kulkarni, PhD
Samuel Kuna, PhD
Ronald Kuntzman, PhD
Gary L Lage, PhD, DABT
Souheil Laham, PhD, CIH
Robert E Larson, PhD
Dr Robert R Lauwerys
W Homer Lawrence, PhD
Leonard J Leach, BS
Insu P Lee, PhD
Margaret I Leonard, PhD
Basil K J Leong, PhD, DABT
George J Levinskas, PhD, DABT
Alan C Levy, PhD
John R Lewis, PhD
Charles L Litterst, PhD
Mei-Tein Lo, PhD
James E Long, ScD
Ted A Loomis, MD, PhD
Dietrich Lorke, MD
Robert T Louis-Ferdinand, PhD
Frank C Lu, MD
Mark M Luckens, PhD
George D Lumb, MD
Yugal K Luthra, PhD
William E MacDonald, PhD
J Douglas MacEwen, PhD, DABT
James T MacGregor, PhD, DABT
Harry Madissoo, DVM
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D Dennis Mahlum, PhD
Roger P Maickel, PhD
Mahin D Maines, PhD
Torbjorn Malmfors, MD, PhD
Barbara R Manno, MS, PhD
Joseph E Manno, Sr, PhD, RPh
Josef Marhold, MD, PhD
Robert R Maronpot, MPH, MS, AVCP, DABT
Hans W J Marquardt, MD
Francis N Marzulli, PhD
Edward J Massaro, PhD
Taijiro Matsushima, PhD
H B Skip Matthews, PhD, DABT
Foster L Mayer, Jr, PhD
Roger O McClellan, DVM, DABT, DABVT, FAT
Donald D McCollister, BS
John R McCoy, DVM
Rob S McCutcheon, PhD
Michael J McKenna, PhD, DABT
Harihara M Mehendale, PhD, DABT
Myron A Mehlman, PhD
Julius J Menn, PhD
Mr John H Mennear, PhD, RPh
Robert E Menzer, PhD
Lowell D Miller, PhD
Harry A Milman, PhD
G Nabi Mir, PhD
Tom S Miya, PhD
Sven Moeschlin, MD
Augustine E Moffitt, Jr, ScD
Mark R Montgomery, PhD
John A Moore, DVM, DABT
Oscar M Moreno, PhD
Paul E Morrow, PhD
Joseph J P Morton, PhD, DABT
Mary Treinen Moslen, PhD
Roy L Mundy, PhD
John I Munn, PhD
Ian C Munro, PhD, MRC Path
Ian C Munro, PhD, FATS, FRC Path
Herbert T Nagasawa, PhD
John H Nair
Velayudhan Nair, PhD, DSc
Paul O Nees, DVM
Dallas L Nelson, DVM, PhD
Karl J Netter, MD
James W Newberne, DVM, PhD
Paul M Newberne, DVM
Gordon W Newell, PhD, ATS
Yasuhiro Noguchi, PhD, MPH, DABT
Granville A Nolen
Gunnar F Nordberg, MD
Stata Norton, PhD
Fred W Oberst, PhD
Frederick W Oehme, DVM, PhD, ATS, DABT,
Kenneth J Olson, PhD
Robert E Osterberg, PhD, ATS
M Alice Ottoboni, PhD
Norris V Owen, DVM PhD
Norbert P Page, MS, DVM, DABT
Edward D Palmes, PhD
Yogendra M Patel, PhD
Harold M Peck, MD
Richard E Peterson, PhD
Vance J Petrella, PhD, JD, DABT
Dr Emil A Pfitzer
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Albert L Picchioni, PhD
Emmet C Pierce, MD
Richard C Piper, PhD
Gabriel L Plaa, PhD, DABT
John J Pollock, PhD
William R Pool, PhD, DABT
Emil Poulsen, DVM, DVSc
John W Poutsiaka, PhD
Iain F H Purchase, PhD
Mary L Quaife, PhD
William A Rader, DVM
Jack L Radomski, PhD
Nathan Rakieten, PhD
Sambasiva Rao, MD
Janardan K Reddy, MD
Krishna Reddy, PhD, DABT
Donald J Reed, PhD
Andrew L Reeves, PhD
Charles F Reinhardt, MD, DABT
Frederick E Reno, PhD
Ralph C Reynolds, BS
William E Ribelin, DVM, PhD
Rudy J Richardson, ScD
William E Rinehart, ScD
Jane F Robens, DVM
Colin N Roberts, PhD
Farrel R Robinson, DVM, PhD
Francis J C Roe, DSc, FRC Path
Lawrence M Roslinski, PhD, DABT
Klaus R Sachsse, DVM
Salah E Sadek, DVM, PhD
Umberto Saffiotti, MD
Harry Salem, PhD
Awni M Sarrif, PhD
B V Rama Sastry, ScD, PhD
Tetsuo Satoh, PhD
Mitchell W Sauerhoff, PhD, DABT
Jack P Saunders, PhD
Daljit S Sawhney, MSc, DVM, PhD, DABT
Robert A Scala, PhD, ATS, DABT, Fellow A
James L Schardein, MS
Donald M Schiavo, DrPH
George J Schieferstein, PhD
Craig Schnell, PhD
Wolfgang K Schnitzlein, DVM
Sorell L Schwartz, PhD
Bernard A Schwetz, DVM, PhD, DABT
David M Serrone, PhD, DABT
Jon L Seymour, PhD
C Boyd Shaffer, PhD
Hasmukh C Shah, PhD, DABT
Zahir A Shaikh, PhD
Ronald C Shank, PhD
Raghubir P Sharma, DVM, PhD, CIH, DABT,
Thomas E Shellenberger, PhD
Martin Sherman, PhD
Samuel I Shibko, PhD
Yasuhiko Shirasu, PhD
Robert D Short, Jr, PhD, DABT
James L Shupe, DVM
Gary J Sibert, DVM, PhD
Melvin R Sikov, PhD
Dineshwar P Sinha, DVM, PhD
I Glenn Sipes, PhD, Fellow ATS
Myron B Slomka, MD PhD
Harry E Smalley, DVM
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Emil R Smith, PhD
Jerry M Smith, PhD, DABT
Roger P Smith, PhD
Thomas H F Smith, PhD
Fred H Snyder, PhD
Robert Snyder, DPhil, ATS
R Duane Sofia, PhD
Peter S Spencer, PhD, FRC Path
James N Stannard, PhD
Robert E Staples, PhD
Charles N Statham, PhD
William B Stavinoha, PhD
Arthur A Stein, MD
Stephen S Sternberg, MD
James T Stevens, PhD, ATS, DABT
Donald E Stevenson, PhD
Richard D Stewart, MD
Gilbert S Stoewsand, PhD
Edwin F Stula, DVM, PhD
Walter E Sultan, BS
F William Sunderman, MD, PhD
F William Sunderman, Jr, MD
George M Szczech, DVM, PhD, DABT
Kiichi Takano, MD
Martin F Tansy, PhD
Robert G Tardiff, PhD, ATS
Jean M Taylor, PhD
Julius D Taylor, PhD
Sait Tekeli, DVM, PhD
Thomas R Tephly, MD, PhD
Anthony A Thomas, MD
John A Thomas, PhD, ATS
Theodore R Torkelson, DSc
Anthony J Triolo, PhD
Henry J Trochimowicz, ScD, DABT
Robert F Turk, PhD
Thomas W Tusing, MD
Hartmut Uehleke
Borge M Ulland, DVM
Charles E Ulrich, BS
Andrew G Ulsamer, PhD
Gary A Van Gelder, MS, DVM, PhD
Edward J Van Loon, PhD
Louis E Van Petten, DVM
Edmond H Vernot, DABT
Slavoljub L Vitorovic, PhD
Mary Vore, PhD
William J Waddell, MD, Fellow ATS
Alan R Wagner, DVM, MSc
Bernard Wagner, MD
A Ian T Walker, PhD
John W Ward, PhD
George Whitaker Ware, PhD
Richard S Waritz, DPhil, ATS, DABT
Philip G Watanabe, PhD, DABT
Michael Watson, PhD, DABT
James L Way, PhD
Lawrence C Weaver, PhD
John H Wedig, PhD, DABT
John H Weikel, Jr, PhD
Myron S Weinberg, DPhil, DABT
Francis W Weir, PhD
Elizabeth K Weisburger, PhD
John H Weisburger
Richard M Welch, PhD
John S Welles, BS
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Bob West, PhD
Kathleen S Weston, MD
Allan G Wheeler, MS
Carrie E Whitmire, PhD
Robert A Wiley, PhD
Chris F Wilkinson, PhD
Paul W Willard, PhD, DABT
Clara H Williams, PhD
Gary M Williams, MD, DABT
Donald A Willigan, DVM, PhD
Dr John E Willson
Benjamin J Wilson, PhD
Charles L Winek, PhD
Hanspeter R Witschi, MD, DABT
Gerald N Wogan, PhD
Anne M Wolven-Garrett, MS
Laurence C K Wong, PhD
Marie W Woodard, MS
James S Woods, PhD, DABT
Lauren A Woods, MD, PhD
Mr Harold M Worth, BA
George J Wright, PhD
Ronald J Wulf, PhD
Raymond S H Yang
Roger A Yeary, DVM, DABT, DABVT, Fellow
Helen C Yen Koo, PhD
David W Yesair, PhD
Shin'Ichi Yoshihara, PhD
Annual Meeting Registration Set to Break Record
SOT is pleased to announce that, to date, over 5,000 attendees have registered for the 2004 Annual
Meeting; almost 700 registrants more than for the same period last year. With over a month left to
register, SOT is anticipating a record number of registrants that would exceed the overall registration
for the San Francisco meeting of 6000+ attendees.
Watch your mail for the SOT Program. In the meantime, visit the 2004 Annual Meeting section of the
Web Site to see what all the excitement is about. All the Annual Meeting information is readily
accessible there.
SOT Announces Student Award Recipients
The Education Committee congratulates the recipients of 2004 SOT student awards, including the
finalists for the Novartis Graduate Fellowship. The finalists are Darrell Boverhoff, Biochemistry and
Molecular Biology Michigan State University; James P. Luyendyk, Pharmacology and Toxicology,
Michigan State University; and Jennifer Marlowe, Department of Health, University of Cincinnati.
These outstanding students receive travel support for their Baltimore interviews. The fellowship
recipient is announced at the Awards Presentation. Fellowship recipients in 2003 are featured on page
32 of the Annual Meeting Program.
Jaya Chilakapati of the University of Louisiana at Monroe will be learning techniques alternative to
traditional whole animal models using Colgate-Palmolive Student Research Training in Alternative
Methods Funding to enhance her dissertation work. She will be working with Frank Witzman at the
Indiana University School of Medicine. Her dissertation involves exploration of thioacetamide
metabolism and toxicity. In vitro techniques will be used to identify major protein adducts and the
influence of dose, time, and dietary restriction on the formation of these adducts.
Opportunities are still available to students who wish to apply for research training funding. To submit
an application, please download the appropriate forms from the SOT Web Site.
The ninety-two students below are receiving Graduate Travel Awards. In addition, the members of the
Student Advisory Committee, composed of a representative from each regional chapter, also receive
travel support from SOT and from their regional chapter.
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Graduate Travel Award Winners:
Lauren M. Aleksunes, University of Connecticut
Reiko Anahara Chiba, University, Japan
David Arrington, Medical University of South Carolina
Elizabeth A. Berg, New York University School of Medicine
Madhavi Billam, Texas Tech University
Jessica A. Bonzo, University of California, San Diego
Brian M. Brock, University of Rhode Island
Jared Brown, University of Montana
Amy B. Cadwallader, University of Utah
Jerry L. Campbell, Jr., University of Georgia
Zhuoxiao Cao, St. John’s University
Amit M. Chaudhary, University of Mississippi
Kathryn J. Chavez, Cornell University
Daesuk Chung, University of Michigan
Jou-Ku Chung, Northeastern University
Alper Coban, Mississippi State University
Stacy M. Corthals, Indiana University School of Medicine
Kristy A. Cortright, University of California, Davis
Kari A. Cox, University of Texas at Austin
Todd L. Davidson, New York University School of Medicine
Jennifer E. Dawson, Queen’s University
James E. Dennison, Colorado State University
Sachin S. Devi, University of Louisiana at Monroe
Julie A. Dobbs, Mississippi State University
Jing Dong, University of Texas Austin/University of Arizona
Melanie L. Doyle, University of North Carolina
Reem H. Elbekai, University of Alberta
Quentin Felty, University of Alabama at Birmingham
Heather S. Floyd, Wake Forest University
Enrique Fuentes, University of Puerto Rico
Thomas Guillot, Emory University
Yingying Guo, University of Washington
Murali Gururajan, University of Kentucky
Natalia L. Harmon, Texas Southern University
Mary Hassani, University of Montana
Juan P. Hernandez, University of Texas at El Paso
Laura Y. Hernandez, University of Texas at El Paso
Brett D. Hollingshead, Pennsylvania State University
Qunshan Jia, Michigan State University
Chirag Kariya, University of Colorado Health Sciences Center
Tisha C. King Heiden, University of Wisconsin-Milwaukee
Hesham M. Korashy, University of Alberta
Marisa L. Kreider, Duke University
Robert K. Kuester, University of Arizona
Takashima Kyoka, Chiba University, Japan
Raymond J. Langley, University of New Mexico
Natalie Lassen, University of Colorado Health Sciences Center
Yafan Li, University of Wisconsin
Xuhong Liu, Texas A&M University
Ying Liu, Texas Tech University
Manupat Lohitnavy, Colorado State University
Amie K. Lund, University of New Mexico
Daniel E.W. Machemer, University of California, San Diego
Jeffrey S. Moffit, University of Connecticut
Mai A. Ngo, University of California, Davis
Trisha L. Noreault, Dartmouth Medical School
Onyinye E. Nwagbara, Florida A&M University
Marcin F. Osuchowski, University of Georgia
Chintan Y. Patel, Long Island University
Amanda D. Phelka, University of Michigan
Melinda J. Pomeroy, Virginia Tech
Marija Popovic, University of Toronto
Christine L. Powell, University of North Carolina at Chapel Hill
Karine Price, University of Montreal
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Xinzhu Pu, Purdue University
Soma S. Ray, University of Kentucky
Mark J. Reimers, Oregon State University
Victoria E. Richards, University of Arizona
Cheryl E. Rockwell, Michigan State University
Lynette K. Rogers, Ohio State University
Sharmilee P. Sawant, University of Louisiana at Monroe
Shengli Shi, University of Washington
Kaul Siddharth, Iowa State University
Arno G. Siraki, University of Toronto
Monica R. Smith, Meharry Medical College
Christopher L. Sprague, University of Wisconsin-Madison
Tingting Sun, University of Mississippi Medical Center
Sabine Teske, Washington State University
Natasha A. Thadani, Queen’s University
Eric S. Tien, Pennsylvania State University
Wachareeporn Trinachartvanit, University of Illinois
Irina V. Ustyugova, West Virginia University
Vimala Vemireddi, Virginia Tech
Thomas Visalli, University of Medicine & Dentistry of New Jersey
Jianyong Wang, University of Arkansas for Medical Sciences
Deena M. Wassenberg, Duke University
Kimberly C. Wise, Texas Southern University
Kristina K. Wolf, Dartmouth Medical School
Amber K. Wyman, University of Rochester
Jianxun Xie, University of Rhode Island
Mei Xu, West Virginia University
Xiaofei Zhang, University of California, Riverside
Career Resource and Development Services at 2004 SOT Meeting in Baltimore
The Placement Center is an important part of the Annual Meeting, providing a coordinated service for
information regarding career opportunities and qualified candidates. The system is computer-based,
and readily available on the SOT Web Site. The Annual Meeting SOT Placement Center continues to
offer both candidates and employers the use of computers, limited to short searches, updates or new
information. In addition, the Career Resource and Development Services offers bulletin board job
listings, employer/candidate mailboxes, and interview booths.
As in previous years, we are asking SOT Job Bank users to plan ahead and input resumes or new job
listings prior to the Annual Meeting. We also encourage you to complete your search for candidates or
jobs prior to the meeting.
Reminders: The on-line SOT Job Bank and the Career Resource and Development Services in Baltimore
are free to all SOT student members if you register before the meeting. The registration fee for the
SOT Career Resource and Development Services for student members will be $20 at the meeting. The
SOT Job Bank Web Site can be easily accessed on your PC prior to the meeting or via your laptop
computer and Internet connection in your room in Baltimore.
Placement Committee Offers Job Search Skills Workshop
A hands-on workshop, sponsored by the SOT Placement Committee, will be offered at the Annual
Meeting, on Monday, March 22 from 4:30 PM – 6:00 PM. This session is designed to encourage
interaction between job seekers, recruiters, and employers in academia, government, and industry.
The workshop will be divided into a question and answer session and a breakout group session. The
first portion will provide attendees with practical information on topics such as the current job market,
what skills employers are looking for, interviewing, and negotiating skills. Audience participation is
highly encouraged. In the second portion, participants will receive advice and counsel from career
placement professionals and other knowledgeable participants. This informal session is geared to assist
attendees with the job search processes. The breakout groups will provide a venue for participants to
have resumes critiqued, job search process concerns addressed, interview skills polished, and career
path possibilities explored. Additionally, this is an excellent opportunity to develop and expand career
Toxicology Program and Internship Recruitment Opportunity at the SOT Annual Meeting
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Representatives from toxicology training programs and student intern/research programs are invited to
meet participants in the Undergraduate Education Program on Sunday afternoon March 21st from 3:00
PM – 5:00 PM in Baltimore Convention Center Room 337. Program directors and other program
representatives are encouraged to come discuss their programs and other opportunities in toxicology
with bright undergraduate students from across the country. The session is open to all Annual Meeting
registrants and SOT members. For more information contact Alice Villalobos or Betty Eidemiller at
SOT Headquarters.
The Society of Toxicology appreciates the generous contributions of the 2004 Annual Meeting
AstraZeneca Pharmaceuticals
Bristol-Myers Squibb Company
The Burroughs Wellcome Fund
Colgate-Palmolive Company
Gene Logic, Inc.
Huntingdon Life Sciences
Pfizer Global Research & Development
Toxicology Education Foundation PLATINUM
Allergan, Inc.
Ani Lytics, Inc.
Aventis Pharmaceuticals, Inc.
Eli Lilly & Company
Allergan, Inc.
Ani Lytics, Inc.
Aventis Pharmaceuticals, Inc.
Eli Lilly & Company
American Chemistry Council
American Petroleum Institute
BAS Evansville
BBL Sciences
The Boeing Company
Chemical Abstracts Services
CIIT Centers for Health Research
Eastman Charitable Foundation
ExxonMobil Biomedical Sciences, Inc.
Merck Research Laboratories
RCC Ltd.
WIL Research Laboratories
Wyeth Research
Abbott Laboratories
Calvert Laboratories, Inc.
Charles River Laboratories
Chiron Corporation
Clorox Company
Covance Laboratories, Inc.
DuPont Haskell Laboratories
EPL, Inc. (Experimental Pathology Labs)
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Hamilton-Kinder, LLC
Hurley Consulting Associates Ltd.
Johnson & Johnson Corporation
Procter & Gamble Company
Purdue Pharma LP
Research Institute for Fragrance Materials
Roche Applied Sciences
SafeBridge Consultants, Inc.
The Sapphire Group, Inc.
Society of Toxicologic Pathology
TAP Pharmaceuticals
Toxicology Excellence for Risk Assessment
In Vitro Technologies, Inc.
The National Library of Medicine
Tecniplast USA, Inc.
Regular Features
Member News:
SOT President Elected to CSSP
It is our honor to announce that SOT President Marion Ehrich has been appointed to the Executive
Board for the Council of Scientific Society Presidents (CSSP). Dr. Ehrich’s term began in December
2003 and will conclude in December 2004.
The Council of Scientific Society Presidents is an organization comprised of the presidents,
presidents-elect and immediate past presidents of over sixty scientific societies and federations. SOT is
a member. Since its inception in 1973, CSSP has served as a strong voice in support of science and
science education, as the premier national science leadership development institute, and as a forum for
open, substantive exchanges on current scientific issues.
To learn more about CSSP, visit their Web Site. Our congratulations to Dr. Ehrich on this prestigious
SOT Past-President Honored with International Achievement Award
SOT Past-President (1990-1991) Dr. Curtis D. Klaassen has the distinction of being honored by the
International Society of Regulatory Toxicology and Pharmacology. Dr. Klaassen was presented with the
2003 International Achievement Award in recognition of his outstanding contributions to the science of
toxicology and pharmacology and its regulatory implications worldwide, and of his magnificent role as
an educator.
Dr. Klaassen’s award citations are numerous and include a 1976 SOT Achievement Award for his
research accomplishments, and a 1993 SOT Education Award. He was cited by Eugene Garfield in
Current Contents (January 18, 1993) as the scientist who had the fourth highest scientific impact
factor in the United States in the study of xenobiotics (drugs and other chemicals), and in 2002 was
named a “Highly Cited Researcher” in Pharmacology (top 0.5%) by the Institute for Scientific
Dr. Klaassen has served as associate editor of a number of journals including the Journal of
Pharmacology and Experimental Therapeutics for 24 years and Toxicology and Applied Pharmacology
for 10 years. More recently he was Editor-in Chief for the SOT journal Toxicological Sciences
It is with great pride that we congratulate Dr. Klaassen on this honor.
SOT Members Volunteer to Serve
Submitted by Linda Birnbaum
Committee appointments were made easier this year by the large number of SOT members who
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volunteered to serve the Society. All appointees were chosen from the hundreds of members who
volunteered. Great efforts were made to involve as many people as possible, and from as diverse
backgrounds as possible.
We truly appreciate the willingness from our members to serve and if you were not appointed this
year, do not be discouraged or disappointed. There always exists the opportunity to serve SOT.
Volunteer information is kept in a database and when opportunities present themselves during the
year, candidates will be contacted.
Please remember that there are also many opportunities for involvement at the SOT Regional Chapter
and Specialty Section level.
Regional Chapter and Specialty Section News:
Northeast Regional Chapter Meeting Highlights
Submitted by Charles Giardina, NESOT President
The Northeast Chapter of the Society of Toxicology (NESOT) held its annual meeting on November 14,
2003 in Cambridge, Massachusetts. Over 100 participants attended this meeting, which featured
engaging lectures from academic and industrial scientists on the role of the proteasome in cell biology
and medicine.
Dr. Kelvin Davies (USC) opened the meeting with an exciting talk on the role of the proteasome in
the cellular response to oxidative stress. He discussed research from his laboratory which point to the
20S proteasome as the primary means of degrading cellular proteins damaged and denatured by
oxidants. The NESOT was also treated to a lecture from Dr. Daniel Finley, Harvard University, a
leader in the field of proteasome research. Dr. Finely focused on the regulation of ubiquitin attachment
to target proteins. With hundreds of potential ubiquitin ligases identified in the human genome, the
regulation of ubiquitin attachment to target proteins is likely to be a key event in many critical cellular
In a series of highly engaging talks, Millennium Pharmaceutical scientists shared their experiences in
the development of a proteasome inhibitor (Velcade) as a cancer therapeutic agent. Dr. Margaret
Read discussed cell culture and animal modeling studies that supported the potential cancer
suppressing actions of Velcade. Dr. Marlene Juedes discussed the toxicological properties of Velcade,
and Dr. Darrell Nix reported data on the pharmacokinetics and organ distribution of this new drug.
These talks were rounded off with promising clinical data on the effectiveness of Velcade in cancer
This meeting included an interactive poster session, in which approximately 35 posters were displayed
by academic and industrial scientists. Poster awards were presented at the meeting. First and second
place were awarded to Jon Moreland, University of Southern Maine and Jianxun Xie, University of
Rhode Island respectively. Michael Thibodeau, NESOT 2002 1st place poster presentation winner,
presented a talk based on his award winning poster on the mechanism of silica-induced macrophage
This NESOT meeting was made possible by strong member support and participation, as well as
financial and organizational assistance from Millennium Pharmaceuticals and Charles River
Watching Washington:
Session on Meeting with Congress to be held at Annual Meeting
Submitted by William Brock
At the Annual Meeting of the Society of Toxicology in Baltimore, the Regulatory Affairs and Legislative
Assistance Committee and the Regulatory and Safety Evaluation Specialty Section will host a
roundtable discussion on Science in the Legislative Process: A Congressional and Scientific View. With
this workshop we were hoping to attract two Congressional speakers to give their point of view about
science in the policy process. Invitations were sent to a number of Congressional members including
Senator Barbara Boxer, Representative Sherwood Boehlert, Senator Barbara Mikulski and
Senator Bill Frist.
As you may have read in the last Communiqué, Congressional representatives generally respond
favorably to their constituents. We therefore asked SOT members in California and New York to also
send letters to their respective Congressional representative further encouraging them to attend the
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Baltimore meeting. Although Senator Boxer and Representative Boehlert had other Congressional
commitments during that time, it is important to note that we did get return calls from their offices
further showing the need for constituent participation in any Congressional initiative. As the organizing
chair of this session, I want to thank those who took time out of their busy schedule to send a letter to
their representative. This did help, as Representative Boehlert sent our request to the Chief of Staff of
the House Science Committee, and because of that request, we were able to secure David Goldston
to speak at our session. We are still working on acquiring a speaker from the Senate.
This experience continues to show that working with Congress takes energy and patience, but the
outcome is beneficial to SOT members and public policy debates.
SOT Responds to Congressman Moran's Dear Colleague Letter
In January 2004, Congressman James P. Moran forwarded a "Dear Colleague" letter to members of
the House urging fellow Congressional leaders to take action in helping to eliminate toxicity testing on
animals by supporting effective non-animal testing methods.
SOT responded by requesting a meeting with Congressman Moran to discuss the issue of toxicity
testing. On February 9, a delegation comprised of SOT constituents from Moran’s district and leaders
from SOT met with Congressman Moran’s Legislative Aide, Austin Derrer. Participants included
Deborah O’Keefe, SOT Headquarters, William J. Brock, RALA Chair, Sydney Green, John
DeSesso, and SOT Members.
The purpose of this meeting was to clarify Moran’s position on the use of animals for testing and to
identify the motive and status for the legislation Moran has proposed. Mr. Derrer explained that the
legislative process was in its initial phase and that Congressman Moran did not support the banning of
animals used for testing. He wants to move towards non-animal testing methods, ultimately using
non-animal methods for testing whenever an alternative method is approved and achieves the same
results. It is the Congressman’s position that the U.S. was lagging behind Europe and other countries
in this effort.
SOT is in position to be of assistance to the Congressman’s office, and to anyone involved in the
legislative process, in crafting balanced legislation and urged that the policy could not get ahead of the
science. Discussion of animal-based test methods mentioned in the Congressman’s memorandum
revealed the limitation and potential risks in the methods proposed. During the meeting the offer was
put forth to prepare an SOT position paper. Although a position statement is premature at this time,
SOT was recognized as a resource for further discussion and for validation of correspondence from the
Congressman related to the matter. Additionally, since Congressman Moran is part of the Committee
on Appropriations, discussion between SOT and Congressman Moran on funding to support non-animal
test methods should occur.
The Congressman and his staff have been invited to attend the upcoming SOT Annual Meeting in
Baltimore, specifically sessions related to in vitro testing methods.
Mr. Durrer agreed that the Congressman will meet with representatives from SOT Council on Thursday,
March 25 for the SOT Congressional visits.
View the Dear Colleague letter in its entirety.
SOT Delegation Meets with Senator Boxer's Staff
On December 9, 2003, a small team of SOT delegates met with Sandra Schubert, Legislative
Assistant to Senator Barbara Boxer (D-CA). The purpose of this meeting was to exchange
information and avail SOT as a resource able to assist Congressional leaders in the legislative process.
Participants at this meeting included SOT President Marion Ehrich, SOT Executive Director Shawn
Lamb, and members of the SOT Regulatory Affairs and Legislative Assistance Committee William J.
Brock and Janis Hulla.
During the meeting, Ms. Schubert stated that toxicology-related information is occasionally needed in
the context of pending legislation, and in these instances it would be beneficial to have immediate
access to expert consultation. Dr. Ehrlich explained that SOT maintains a list of members having
communication skills in specific areas of expertise. Ms. Schubert indicated that SOT was headed in the
right direction with sponsoring Congressional Science Briefings but noted that a briefing devoted to
toxicological fundamentals should be considered. Ms. Schubert suggested that Senator Boxer’s office
would consider co-sponsoring the event; it is believed that this briefing would be well attended by
legislative staffers.
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How the SOT might be responsive in this context will be discussed at the RALA committee meeting
during the March 2004 Annual Meeting in Baltimore.
In Memoriam:
SOT Founding Member Mourned: Tribute to Frederick Coulston
The Society of Toxicology (SOT) announces with great sadness the loss of Frederick Coulston.
Dr. Coulston passed away on December 15, 2003, at the age of 89, in Alamogordo, New Mexico. The
SOT family will remember him as a founder of the Society and for his devoted service as SOT President
from 1965-1966.
As an active member of SOT, Dr. Coulston was the recipient of several awards, including the SOT Merit
Award in 1975 and the Arnold J. Lehman Award in 1985. Dr. Coulston’s professional accomplishments
are numerous and include his work to develop tests for malaria, AIDS and hepatitis.
Tireless and dedicated, Dr. Coulston published countless scientific articles and served as editor for
several scientific journals including Toxicology and Applied Pharmacology.
It is without a doubt that he will be remembered for his many contributions to toxicology, and he will
be sorely missed.
SOT Member Mourned: Dr. Marshall Steinberg
Dr. Marshall Steinberg passed away on November 9, 2003.
Dr. Steinberg was born in Pittsburgh, PA and received a bachelor’s degree in biology from Georgetown
University, a master’s degree in Zoology from the University of Pittsburgh and a doctoral degree in
Pharmacology and Toxicology from the University of Texas.
A 20-year U.S. Army veteran, Dr. Steinberg retired with the rank of Colonel. Following his retirement,
Dr. Steinberg held senior positions as Principal Investigator in the National Cancer Institute Bioassay
Program and as Vice President at both Hazleton Laboratories and Hercules Inc. He retired from the
latter company in 1997.
Dr. Steinberg was a consultant to the Environmental Protection Agency’s pesticide program and
adjunct professor at American University. During his career, Dr. Steinberg was active in several
scientific organizations including the Society of Toxicology, Academy of Toxicological Sciences, and the
American College of Toxicology, where he served a term as president. He also was a Fellow of the
Royal Society of Medicine in the UK.
He served as International Pharmaceutical Excipients Council of the Americas (IPEC-Americas) Safety
Committee Chair from 1992 through 1997 where he was heavily involved in the development and
subsequent acceptance of the IPEC guidelines for safety assessment of new pharmaceutical excipients
by the FDA new drug reviewers and later US Pharmacopeia. Following his term as Chair of
IPEC-Americas (1999-2000), Dr. Steinberg served as Chair of International Pharmaceutical Excipients
Auditing, Inc., until shortly before his death. He published more than 130 professional technical papers
and book chapters.
Survivors include his wife of 42 years, Patricia Louise Zobac Steinberg and three children, Leslie
Shifrin, Michael Steinberg, and Maureen Steinberg.
Dr. Steinberg was interred in Arlington National Cemetery on November 20, 2003 with full military
In Memoriam
Frederick Coulston
Ben Van Duuren
Perry Gerhring
Marshall Steinberg
Willard Weatherholtz
Career Resource and Development Services:
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Toxicology Manager
You will be responsible for in vitro and in vivo toxicology studies to support drug discovery and
development activities. You will help design in house toxicology studies as well as manage the
outsourced safety assessment studies in support of regulatory filings generating preclinical regulatory
documentation. You will be a key representative of toxicology on programs teams, and participate in
discovery to development strategies. Requires Ph.D. degree in Toxicology or relevant discipline, and/or
DVM with at least 5 years relevant experience in industrial pharmaceutical toxicology. Board
certification (DABT) is a plus.
Come join us and receive great compensation and benefits that include 401(k) match, 3 weeks
vacation, stock options/ purchase plan, and a motivated team-oriented environment. Please apply
on-line, or send your resume to: Neurocrine Biosciences, Inc., 10555 Science Center Drive, San Diego,
CA, 92121. EOE.
The Health and Safety Communication Department of the Oak Ridge Institute for Science and
Education operated by Oak Ridge Associated Universities under contract with U.S. Department of
Energy, is seeking two Toxicologists plus subcontractors. One employment position (Reference #
04-002) is Full-Time Temporary Up to One Year and the second employment position (Reference #
04-058) is Full-Time Regular. Duties of the employee/subcontractor positions will be to research,
retrieve and collate information on human health/toxicology of potentially harmful chemicals and to
write Toxicological Reviews and Summaries for the U.S. Environmental Protection Agency (EPA)
Integrated Risk Information System (IRIS) database.
REQUIREMENTS: Ph.D. in Toxicology or Biochemistry and four to six years of related experience. Must
be an expert in environmental toxicology and biochemistry, with a working knowledge of risk
assessment, chemical analysis, human health sciences, and biomedical research. Must have
demonstrated ability in research and oral presentations. Required experience includes writing
toxicological reviews and summaries, leading and participating in teams for scientific reviews and
report preparation, and developing work plans and budgets.
To Request Consideration: Please visit our representatives at Career Resource and Development
Services during the March Annual Meeting or you may send your resume (Specify Reference # 04-002;
Reference # 04-058; or Toxicology Subcontractor and include your salary requirements) via e-mail to
[email protected] or by mail to: Oak Ridge Associated Universities, Employment, MS-31, P.O. Box
117, Oak Ridge, TN 37831-0117. ORAU is an EEO/AA employer and maintains a drug free workplace.
Post-Doctoral Fellowship in Environmental Pathology
The NIEHS-funded Training Program in Environmental pathology at Brown University invites applicants
for a post-doctoral research fellowship. This is an interdisciplinary training program that applies the
tools of biochemistry, molecular biology, and cell biology to study the pathogenesis of cancer,
reproductive and neurologic toxicity, and stress, altered immune responses, and early pregnancy loss
related to environmental exposure. This training program provides opportunities for teaching
experience, grantsmanship workshops, and career development activities. Trainees are expected to
have a M.D. or Ph.D. degree in biology or chemistry and must be a U.S. citizen or permanent resident.
Commitment to a research career in environmental pathology is essential. Research space will be
provided in newly renovated laboratories with modern core facilities for genomics, proteomics,
transgenic mice, molecular pathology, cell imaging, flow cytometry, and a human tumor bank.
Research mentors: Jorge Albina (inflammation and tissue repair), Christine Biron (stress and innate
immunity), Kim Boekelheide (reproductive toxicology), Suzanne de la Monte (neurodegenerative
disease), A. Ray Frackelton (signaling pathways in cancer), Douglas Hixson (stem cells and liver
carcinogenesis), Agnes B. Kane (toxicology of asbestos and nanofibers), James Padbury and Surendra
Sharma (stress, nutritional deprivation, and early pregnancy loss), Nancy Thompson (molecular
mechanisms of liver carcinogenesis), Anatoly Zhitkovich (metal toxicology and carcinogenesis).
Applicants should submit a curriculum vitae, recent publications, a description of career objectives, and
three letters of recommendation to: Agnes B. Kane, M.D., Ph.D., Professor and Chair, Department of
Pathology and Laboratory Medicine, Brown University, Box G-B529, Providence, RI 02912. Fax: (401)
863-9008. E-mail: [email protected] Review of applications will commence on March 1, 2004
and will continue until the position is filled. Brown University is an EEO-AA Employer and welcomes
applications from minorities and women.
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Associate Director Toxicology
Minimum Requirements: Ph.D. Degree in Toxicology, or related discipline, with 10+ years of
experience and board certification in toxicology. Candidates must possess strong interpersonal skills
and interact with colleagues at all levels. Ability to manage multiple projects and assignments under
demanding time schedules is essential.
Position Summary: Plan, develop strategy, and evaluate and assess safety of consumer healthcare
products as well as compliance with appropriate regulatory requirements. Develop and implement a
safety assessment strategy for consumer products for Global Marketing. Supervise, monitor, and
conduct safety evaluations for product registrations in European and other Non-U.S. markets. Review
IND/NDA and 510(K) submissions, as well as evaluate Safety/Pharmacology and Pharmacokinetics of
external licensing candidates and RX-to-OTC switches. Provide Pathology expertise on safety
assessment of products as necessary.
Represent as Toxicology expert on project teams and for multiple business groups, as well as in
external meetings with regulatory authorities. Familiarity with GLP and GCP is essential. Interaction
with Inter-Departmental and Inter-Divisional colleagues required at all levels. Please submit resumes
to: [email protected]
Professor GEO and Director Academic Medicine
Applications and nominations are invited for Chair of the Department of Environmental Health at the
University of Cincinnati, College of Medicine. The department ranks fourth out of 54 Departments of
Environmental Health associated with Colleges of Medicine; has been awarded three NIEHS Center
Grants; and is nationally recognized for its major areas of expertise in environmental exposure and
genetics of complex diseases, molecular and cellular toxicology, carcinogenesis, environmentalindustrial hygiene and chemistry, occupational and environmental medicine, biostatistics, epidemiology
and policy and risk assessment. Collaborative research and training programs involve the Colleges of
Medicine, Engineering and Arts and Sciences, and the Children’s Hospital Research Foundation. The
Chair will have the opportunity to build on existing strengths and to expand the department in new
directions through implementation of new programs and recruitment of faculty. The department
currently has 43 full-time faculty members and over 100 graduate students and post-doctoral fellows.
It is housed in an independent research complex with outstanding laboratory, office and classroom
We seek an individual with an internationally recognized research program in an environmental health
science area and who has a strong commitment to graduate education. The successful candidate must
have a Ph.D. and/or M.D. or equivalent, demonstrated leadership skills, and a vision for the future
advancement of environmental health science both within the department and in collaboration with
other units of the
The position is open until filled. Interested applicants should submit letter of application noting control
# 23UC0263, curriculum vitae and the names of three references to: Thomas A. Boat, M.D., Search
Committee Chair, c/o Office of Faculty and Administrative Affairs, University of Cincinnati College of
Medicine, 231 Albert Sabin Way, P.O. Box 670554, Cincinnati OH 45267-0554, Attn: Environmental
Health Search, or send an e-mail to: Thomas Boat at [email protected] or Amy Carpenter at
[email protected] Affirmative Action/Equal Opportunity Employer
ChemRisk is a consulting firm providing state-of-the-art toxicology, industrial hygiene, epidemiology,
and risk assessment services to organizations that confront public health, occupational health, and
environmental challenges. ChemRisk is seeking applicants with training in toxicology, pharmacology,
the environmental sciences, risk assessment, biomedical engineering, industrial hygiene, medicine or
health physics.
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This position requires a Bachelor’s degree in environmental or toxicological sciences. Candidates with a
Master’s degree in environmental sciences and a minimum of 1-3 years experience are preferred.
Candidates with a background in consulting are especially desired.
ChemRisk offers an excellent benefits package, including company-subsidized medical, dental, vision,
and a 401(k) Retirement Program. We are an Equal Opportunity Employer.
Please send resumes to: Human Resources, ChemRisk, 100 Spear Street, Suite 525, San Francisco, CA
94105 or [email protected] Visit us on the Web at, or contact us by phone
at (415) 896-2400, or fax (415) 896-2444.
Access SOT On-Line Career Resource and Development Services
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